Clinical trial Recruiting at 1 site Interventional Ages 18 to 40 Women only

Using lubrication gel during embryo transfer in IVF

Official title: Lubricant Gel Versus Sterile Water for Speculum Insertion During Embryo Transfer: a Randomized Non-inferiority Clinical Trial

Run by Wolfson Medical Center · NCT06210451 · Data updated 2026-11-12

This study is testing whether using a special lubrication gel during embryo transfer in IVF can help women aged 18-40 have a higher chance of a live birth.

Quick facts

Study typeInterventional
Ages18 Years to 40 Years
SexWomen only
Enrollment416 (estimated)
SponsorWolfson Medical Center
Government
Locations1 site (Tel Aviv)
StatusRecruiting
StartedMay 1, 2024
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedJuly 24, 2024
Trial IDNCT06210451 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are women aged 18-40 undergoing their first to third embryo transfer with fresh or thawed embryos.

Probably not a fit

Patients over the age of 40 or those undergoing egg donation cycles may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of using a sterile water-based lubrication gel during the embryo transfer (ET) process in in vitro fertilization (IVF). The study aims to determine whether the gel affects the live birth rate per transfer, addressing concerns that it may hinder ET success. Participants will include women aged 18-40 undergoing their first to third ET with fresh or thawed embryos. The trial will compare outcomes between those who receive the gel and those who do not, contributing to the understanding of best practices in embryo transfer.

Why it matters

Potential benefit: If successful, this study could enhance patient comfort during embryo transfer without compromising the chances of a successful pregnancy.

How similar studies have gone: Previous studies have shown that the use of small amounts of water-soluble gel does not negatively impact cervical cytology, suggesting potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18-40
* Fresh and thawed ET
* Patients undergoing their 1st-3rd ET
* ET of 1-2 embryos

Exclusion Criteria:

* Age\>40
* Egg donation cycles

Where it's running

  • Faculty of Medical and Health Sciences
    Tel Aviv, Israel
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.