Using laser and photodynamic therapy to treat periodontitis
Efficacy of Photodynamic Therapy and LASER Disinfection as Adjunct to Nonsurgical Periodontal Therapy for Treatment of Periodontitis: Randomized Clinical Trial
This study is testing whether adding laser and light therapy to regular dental cleaning can help people with gum disease feel better and improve their oral health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 18 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Baghdad Academic / other |
| Locations | 1 site (Baghdad) |
| Trial ID | NCT06305533 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of laser disinfection and ICG-mediated photodynamic therapy as adjuncts to root surface debridement in patients with periodontitis. Participants will receive full-mouth supragingival debridement and will be randomly assigned to either a control group or treatment groups that will receive additional therapies. The study aims to assess improvements in clinical parameters and reductions in periodontal pathogens after treatment. All patients will follow a standardized oral hygiene regimen throughout the trial.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old, non-smokers, diagnosed with generalized periodontitis, and not currently undergoing other periodontal treatments.
Not a fit: Patients who smoke, have systemic diseases like diabetes, or have received recent periodontal treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective treatments for periodontitis, improving oral health outcomes for patients.
How similar studies have performed: While similar approaches have been explored, this specific combination of therapies is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult subjects (\>18 years), non-smoker, with no history of any systemic disease such as diabetes mellitus. Additionally, subjects are not currently under active periodontal therapy or joining other trial in the last 3 months. All patients must be diagnosed with generalized periodontitis with at least 3 teeth in three different sextants (Anterior teeth and premolars) with 4-6 mm PPD and positive BOP. Periodontitis cases will be defined by presence of interdental CAL affecting ≥2 non adjacent teeth or if CAL at buccal/lingual aspects associated with PPD \>4mm at ≥2 teeth. Exclusion Criteria: * Patients will be excluded if they were not diagnosed with periodontitis, smokers, those consuming antibiotics, regular user of nonsteroidal anti-inflammatory drugs, or receiving periodontal treatment 3-months prior to the study. Additionally, pregnant or mothers in a breastfeeding period, and those not willing to participate will be also excluded.
Where this trial is running
Baghdad
- College of Dentistry, University of Baghdad — Baghdad, Iraq (Recruiting)
Study contacts
- Study coordinator: Zahraa Talib, B.D.S
- Email: zahraa.abd2205@codental.uobaghdad.edu.iq
- Phone: 009647724342248
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.