Using laser and photodynamic therapy to treat periodontitis
Official title: Efficacy of Photodynamic Therapy and LASER Disinfection as Adjunct to Nonsurgical Periodontal Therapy for Treatment of Periodontitis: Randomized Clinical Trial
Run by University of Baghdad · NCT06305533 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether adding laser and light therapy to regular dental cleaning can help people with gum disease feel better and improve their oral health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 18 (estimated) |
| Sponsor | University of Baghdad Academic / other |
| Locations | 1 site (Baghdad) |
| Trial ID | NCT06305533 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old, non-smokers, diagnosed with generalized periodontitis, and not currently undergoing other periodontal treatments.
✕Probably not a fit
Patients who smoke, have systemic diseases like diabetes, or have received recent periodontal treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of laser disinfection and ICG-mediated photodynamic therapy as adjuncts to root surface debridement in patients with periodontitis. Participants will receive full-mouth supragingival debridement and will be randomly assigned to either a control group or treatment groups that will receive additional therapies. The study aims to assess improvements in clinical parameters and reductions in periodontal pathogens after treatment. All patients will follow a standardized oral hygiene regimen throughout the trial.
Why it matters
Potential benefit: If successful, this approach could lead to more effective treatments for periodontitis, improving oral health outcomes for patients.
How similar studies have gone: While similar approaches have been explored, this specific combination of therapies is novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult subjects (\>18 years), non-smoker, with no history of any systemic disease such as diabetes mellitus. Additionally, subjects are not currently under active periodontal therapy or joining other trial in the last 3 months. All patients must be diagnosed with generalized periodontitis with at least 3 teeth in three different sextants (Anterior teeth and premolars) with 4-6 mm PPD and positive BOP. Periodontitis cases will be defined by presence of interdental CAL affecting ≥2 non adjacent teeth or if CAL at buccal/lingual aspects associated with PPD \>4mm at ≥2 teeth. Exclusion Criteria: * Patients will be excluded if they were not diagnosed with periodontitis, smokers, those consuming antibiotics, regular user of nonsteroidal anti-inflammatory drugs, or receiving periodontal treatment 3-months prior to the study. Additionally, pregnant or mothers in a breastfeeding period, and those not willing to participate will be also excluded.
Where it's running
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College of Dentistry, University of Baghdad
Baghdad, Iraq Recruiting
Study contacts
- Study coordinator: Zahraa Talib, B.D.S
- Email: zahraa.abd2205@codental.uobaghdad.edu.iq
- Phone: 009647724342248
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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High BMI and periodontitis in Thai adults under 60
This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.
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Association Between Periodontitis and Dry Eye Disease in Adults
This study tests whether periodontitis and dry eye disease are linked by comparing groups with and without each condition.
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Periodontal Infection and Inflammatory Markers in Missed Abortion
Researchers will test whether gum infection and inflammation are linked to missed abortion in pregnant women with no major chromosomal problems.
-
Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease
This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.
-
Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment
This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.
-
Boron, Oxidative Stress, and Inflammation in Periodontitis
This observational study compares boron levels and inflammation markers in saliva and gum tissue between people with periodontitis and healthy controls to see if boron relates to gum inflammation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.