EIT-guided PEEP personalization for trauma- and postoperative ARDS
Official title: Electrical Impedance Tomography-Guided Positive End-Expiratory Pressure Optimization in Patients With Trauma-Related and Postoperative Acute Respiratory Distress Syndrome
Run by Vietnam Military Medical University · NCT07313644 · Data updated 2026-11-12
This trial tests whether using bedside electrical impedance tomography (EIT) to set PEEP helps adults with moderate to severe ARDS after trauma or major surgery breathe and oxygenate better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Vietnam Military Medical University Academic / other |
| Locations | 1 site (Hanoi) |
| Status | Recruiting |
| Started | March 15, 2025 |
| Main results expected | August 15, 2026 |
| Study ends | December 15, 2026 |
| Registry record updated | January 2, 2026 |
| Trial ID | NCT07313644 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult (18–90) intubated surgical ICU patients with trauma- or postoperative-associated moderate to severe ARDS who meet inclusion criteria and lack exclusion conditions.
✕Probably not a fit
Patients with contraindications such as pneumothorax or pneumomediastinum, severe brain injury, end‑stage disease, pregnancy or implanted electrical devices, or those already on advanced respiratory therapies are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center, prospective randomized controlled trial enrolled adult intubated patients with moderate to severe ARDS following trauma or major surgery. Patients were randomized to PEEP titration guided by electrical impedance tomography (EIT) using a standardized protocol with deep sedation versus conventional lower PEEP/FiO2 settings per the ARDSNet table. The primary outcomes were oxygenation and respiratory mechanics, with secondary outcomes including 28-day survival, ventilator-free days, ICU and hospital length of stay, weaning success, adjunctive therapy use, barotrauma, and SOFA score changes. Supportive care and other ventilator settings followed ARDS Network recommendations throughout the study.
Why it matters
Potential benefit: If successful, EIT-guided PEEP could provide more individualized lung protection, improving oxygenation and respiratory mechanics while potentially reducing ventilator days and barotrauma.
How similar studies have gone: Prior small trials and observational work have shown that EIT can improve regional ventilation targeting and short-term oxygenation, but clear evidence of improved clinical outcomes remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Mechanically ventilated surgical intensive care patients with trauma- or postoperative-associated moderate to severe ARDS, as defined by the 2023 Global Definition of ARDS. Exclusion Criteria: * Age \<18 or \>90 years. * Severe acute brain injury or acute stroke with Glasgow Coma Scale \<8. * Thoracic trauma with pneumothorax or pneumomediastinum. * End-stage diseases under palliative care (e.g., metastatic cancer, cirrhosis, end-stage renal disease). * Severe multiorgan failure with expected survival \<7 days. * Conditions requiring prolonged mechanical ventilation (e.g., Guillain-Barré syndrome, cervical spinal cord injury). * Contraindications to hypercapnia (e.g., elevated intracranial pressure, acute coronary syndrome). * Prior use of advanced respiratory therapies (e.g., ECMO, inhaled nitric oxide, prone positioning, high-frequency ventilation). * Pregnancy, breastfeeding, or skin lesions at electrode placement sites. * Implanted electrical devices interfering with EIT (e.g., pacemaker, ICD). * Known allergy to electrode materials. * Refusal to participate or concurrent enrollment in another study
Where it's running
-
Center for Anesthesia and Surgical Intensive Care, Viet Duc University Hospital
Hanoi, Vietnam Recruiting
Study contacts
- Study coordinator: Nguyen Viet Minh
- Email: vietminh1510@gmail.com
- Phone: (+84) 918292528
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.