Understanding immune patterns and ECMO strategies to help adults with severe ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project seeks to classify moderate-to-severe ARDS patients into distinct immune- and clinical-based phenotypes and identify targeted therapeutic approaches for each. It investigates molecular mechanisms behind ECMO-related complications and how immune biomarkers relate to benefits from awake ECMO. The study also aims to define a precision intervention pathway for ECMO management across the patient journey, using data collected from multiple Chinese centers. By examining heterogeneity in ARDS and the immune response during ECMO, the research intends to inform more effective, individualized management strategies. Overall, the work addresses high mortality and resource use in ARDS by seeking to tailor ECMO and ventilation approaches to patient-specific biology.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1.Age ≥ 18 years 2.Meet the global new definition of moderate-to-severe Acute Respiratory Distress Syndrome (ARDS).

Exclusion Criteria:

\- 1.Patients with a prior tracheostomy. 2.Patients who have received a lung transplant or initiated VV-ECMO support as a bridge to lung transplantation.

3.Patients with comorbid cardiogenic shock requiring VA-ECMO or VAV-ECMO support.

Where it's running

• Beijing Anzhen Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting
• Fujian Provincial Hospital
  Fuzhou, Fujian, China Recruiting
• Zhongda Hospital, Southeast University
  Nanjing, Jiangsu, China Recruiting
• Qilu Hospital of Shandong University
  Jinan, Shandong, China Recruiting
• Sichuan Provincial People's Hospital
  Chengdu, Sichuan, China Recruiting
• The Second Affiliated Hospital, Zhejiang University School of Medicine
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: yingzi Huang Yingzi，Huang
• Email: yz_huang@126.com
• Phone: 18271428804

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Dexamethasone for sepsis-related ARDS in adults on ventilatory support

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• NIRS for EDResp: Which first helps hypoxemic adults best?

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• Sodium bicarbonate with bedside electrical impedance tomography to map lung blood flow in ventilated adults

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  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07542366

• How torso tilt and ventilator PEEP affect lung opening in ARDS

  This study will see if tilting the patient's torso and changing PEEP helps open more lung and improve breathing mechanics in adults with moderate to severe ARDS on a ventilator.

  Recruiting at 2 sites Zhongda Hospital · Nanjing, Jiangsu and 2 other locations · NCT07504731

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.