Understanding how periodontal treatment affects sepsis and heart disease
Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis
This study is trying to see how treating gum disease might affect the risk of sepsis and heart problems by looking at the bacteria involved and their impact on health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Sex | All |
| Sponsor | Malmö University Academic / other |
| Locations | 1 site (Lund) |
| Trial ID | NCT04565691 on ClinicalTrials.gov |
What this trial studies
This study investigates the relationship between bacteremia resulting from periodontal treatment and its implications for sepsis and cardiovascular disease. It aims to identify biological markers that indicate current or past bacteremia and to evaluate the long-term effects of treating periodontal disease on cardiovascular health. The study will compare outcomes between treated and untreated groups, focusing on the role of antimicrobial peptides and bacterial proteases in the severity of bacteremia. By utilizing non-surgical periodontal treatment as a model, the research seeks to uncover critical insights into the pathophysiology of sepsis and its connection to oral health.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with periodontal disease.
Not a fit: Patients who have recently used antibiotics may not benefit from this study due to potential confounding effects on bacteremia.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for sepsis and cardiovascular diseases linked to periodontal health.
How similar studies have performed: While the specific approach of this study is novel, previous studies have indicated a connection between periodontal disease and systemic health, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Periodontal disease Exclusion Criteria: * Recently used antibiotics.
Where this trial is running
Lund
- Folktandvarden Skane — Lund, Sweden (Recruiting)
Study contacts
- Principal investigator: Daniel Jonsson, DDS PhD — Malmo University, Lund University
- Study coordinator: Daniel Jonsson, DDS, PhD
- Email: daniel.jonsson@med.lu.se
- Phone: +46462759180
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.