Understanding how Azacitidine resistance develops in certain blood cancers
Official title: Characterization of the Mechanisms of Action of Resistance to Azacitidine in High-risk Myelodysplastic Syndromes and Acute Myeloid Leukemia With Multilineage Dysplasia
Run by Centre Hospitalier Universitaire de Nice · NCT01210274 · Data updated 2026-11-12
This study looks at how some patients with high-risk blood cancers stop responding to the treatment Azacitidine to help find better ways to fight these diseases.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 4 sites (Antibes and 3 other locations) |
| Status | Recruiting |
| Started | September 2010 |
| Main results expected | September 2014 |
| Study ends | September 2025 |
| Registry record updated | March 19, 2025 |
| Trial ID | NCT01210274 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older with high-risk or intermediate 2 MDS or AML with multilineage dysplasia who have received at least three to six cycles of Azacitidine.
✕Probably not a fit
Patients who have received other chemotherapies or those with lower-risk MDS may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to characterize the molecular mechanisms of resistance to Azacitidine in patients with high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) with multilineage dysplasia. It focuses on understanding how Azacitidine, a treatment known for its DNA demethylation effects, influences cell death programs such as apoptosis and autophagy in leukemic cells. By analyzing patients who have undergone multiple cycles of Azacitidine, the study seeks to uncover the biological factors that contribute to treatment resistance. This research could provide insights into improving therapeutic strategies for these conditions.
Why it matters
Potential benefit: If successful, this study could lead to enhanced treatment strategies for patients with high-risk MDS and AML, potentially improving their outcomes.
How similar studies have gone: While the mechanisms of Azacitidine have been explored, this specific focus on resistance mechanisms is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * High Risk or Intermediate 2 MDS (IPSS) * AML-MD (WHO classification) * Treatment with minimum three to six cycles of Azacitidine * Informed consent form signed Exclusion Criteria: * Treatment with others chemotherapies alone or in association
Where it's running
-
CH d'Antibes
Antibes, France Recruiting -
CHU de Nice - Hôpital de l'Archet
Nice, France Recruiting -
Centre Antoine Lacassagne
Nice, France Recruiting -
CH Princesse Grace
Monaco, Monaco Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.