Understanding brain fluid flow in Type I Chiari Malformation
Official title: Analysis of Disturbances in Neurofluid Dynamics in Type I Chiari Malformations
Run by Centre Hospitalier Universitaire, Amiens · NCT06502431 · Data updated 2026-11-12
Researchers will test how cerebrospinal fluid and blood flow behave in people with type I Chiari malformation compared to people without the condition.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens, Picardie) |
| Status | Recruiting |
| Started | June 24, 2024 |
| Main results expected | April 1, 2025 |
| Study ends | July 2027 |
| Registry record updated | September 8, 2026 |
| Trial ID | NCT06502431 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18–50 with major symptomatic or non-symptomatic Type I Chiari malformation and no prior neurosurgical, neurological, or cardiological history, plus age-matched controls without such history.
✕Probably not a fit
Patients with MRI contraindications, pregnancy, or those outside the age range or with conflicting medical histories may not benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study analyzes craniospinal hemodynamics and hydrodynamics using phase-contrast MRI to measure CSF flow and blood flow at multiple intracranial and upper spinal sites. It compares symptomatic and non-symptomatic individuals with Chiari malformation against age-matched controls to understand the role of flow dynamics in the condition. The focus includes intraventricular CSF movement, foramen magnum regions, syringomyelia cavities when present, and pulsatility of the cerebellar tonsils. Data will be collected from high cervical and intracranial vessels to characterize overall hydrodynamics. The study uses noninvasive imaging sequences and does not involve drug interventions.
Why it matters
Potential benefit: If successful, the findings could improve understanding of Chiari malformation biology and guide non-surgical management or imaging-based risk stratification.
How similar studies have gone: Previous work using phase-contrast MRI has shown that CSF and cerebral hemodynamics can be measured noninvasively, supporting the feasibility of similar analyses in Chiari patients.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients with major symptomatic or nonsymptomatic CMI * aged 18 to 50 years * no previous neurosurgical, neurological, or cardiological history. * Controls should be age-matched to symptomatic CMI group. They should not have a history of neurosurgery, neurology, or cardiology. Exclusion Criteria: * Patients who are minors or over 50 years of age * CMI invalidated by our radiological review * Neurosurgical, neurological or cardiological history * MRI contraindication * pregnant, breast-feeding and parturient women
Where it's running
-
CHU Amiens Picardie
Amiens, Picardie, France Recruiting
Study contacts
- Study coordinator: Cyrille Capel, MD
- Email: capel.cyrille@chu-amiens.fr
- Phone: 0322088947
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.