Understanding post‑cardiac arrest brain injury through spinal fluid molecular analysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The protocol collects cerebrospinal fluid (CSF) from patients receiving post‑resuscitation care after out‑of‑hospital cardiac arrest and performs multi‑omics profiling across the genome, transcriptome, proteome, and metabolome. Identified molecular pathways will be compared with drug databases and used in computational modeling to nominate existing compounds or design new candidates. Promising candidates will be synthesized and prioritized to provide rationale for future preclinical experiments in cardiac arrest animal models. Patients with contraindications to lumbar puncture, evidence of cerebral edema, or those treated with ECMO are excluded from sampling.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients receiving post-resuscitation care after out-of-hospital cardiac arrest for secondary brain injury treatment.
* Patients without contraindications for lumbar puncture catheter insertion for cerebrospinal fluid (CSF) collection. This includes the absence of:
* Uncontrolled diabetes.Coagulation disorders.
* Thrombocytopenia (platelet count $\< 100,000).
* A history of cirrhosis diagnosis.
* Current receipt of low molecular weight heparin.
* Current use of platelet inhibitors.
* A history of posterior spinal fusion that may interfere with catheter insertion.
* Local skin infection or rash at the puncture site.
* Signs of systemic infection or sepsis.
* A history of lumbar puncture within the past 6 hours.

Exclusion Criteria:

* Cerebral Edema: Patients with evidence of cerebral edema on a brain computed tomography (CT) scan performed immediately after spontaneous circulation recovery.
* Patients who underwent extracorporeal membrane oxygenation (ECMO).
* Patients who could not maintain integrated therapy for more than 24 hours after cardiac arrest.
* Patients with a history of acute or chronic brain disease.

Where it's running

• Chungnam National University Hospital
  Daejeon, Jung-gu, South Korea Recruiting

Study contacts

• Study coordinator: Changshin Kang, MD. PhD
• Email: rosc@cnu.ac.kr
• Phone: +821089928386

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.