Tramadol vs Morphine for Postoperative Pain After Laparoscopic Abdominal Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares tramadol and morphine for postoperative pain control in adults undergoing laparoscopic abdominal surgery, within a multimodal analgesia framework. It aims to reflect current clinical practices and assess tolerability and safety profiles. The trial examines induction and maintenance anesthesia, plus multimodal analgesia strategies, to determine if tramadol can match morphine in effectiveness while potentially differing in side effects. Participants will be adults aged 18 or older with planned procedures lasting at least two hours and who are enrolled through social security systems, with informed consent required. Exclusion criteria include allergies to common analgesics, contraindications to study drugs, chronic certain enzyme inhibitors, high-risk surgery, psychiatric conditions, and other factors that could confound results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Patient undergoing scheduled laparoscopic abdominal surgery lasting an estimated 2 hours or more.
* Patient affiliated to the social security system.
* Patient signature of consent to participate in the study

Exclusion Criteria:

* Allergy or intolerance to any of the following medicines: paracetamol, nefopam, ketoprofen, tramadol, morphine, Sufentanil, lidocaine, propofol, ketamine, dexamethasone and droleptan.
* Contraindications to any of these medicines: paracetamol, ketoprofen, nefopam, tramadol, morphine, Sufentanil, lidocaine, propofol, ketamine, dexamethasone and droleptan (see Summaries of Product Characteristics).
* Chronic use of monoamine oxidase inhibitors or CYP 450 2D6 inhibitors
* Chronic use of level 2 or 3 analgesics preoperatively
* Ambulatory surgery
* Surgery requiring post-operative admission to an intensive care unit.
* Patients on long-term oxygen therapy
* Patients suffering from psychiatric pathologies.
* Patient suffering from neurodegenerative pathologies
* Patient for whom self-assessment of pain using an NRS (0-10) cannot be carried out (language barrier, etc.)
* Pregnant or breast-feeding woman
* Patient under guardianship or deprived of liberty.

Where it's running

• CHU Amiens-Picardie
  Amiens, France Recruiting

Study contacts

• Study coordinator: Paul Tarpin, MD
• Email: tarpin.paul@chu-amiens.fr
• Phone: 33+322089108

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.