Deep phenotyping to explore recovery in young adults after stroke
Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke
The Florey Institute of Neuroscience and Mental Health · NCT07019493
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | The Florey Institute of Neuroscience and Mental Health (other) |
| Locations | 2 sites (Heidelberg, Victoria and 1 other locations) |
| Trial ID | NCT07019493 on ClinicalTrials.gov |
What this trial studies
This is a small, observational pilot across Melbourne hospitals enrolling up to 100 young adults with recent stroke. Participants undergo comprehensive data collection and biological sampling to create a detailed picture of their health and recovery. The study will measure feasibility outcomes such as practicality, consistency, and participant acceptability of the deep phenotyping protocol. Investigators will also explore relationships between biomarkers, demographics (age, sex), stroke type, lifestyle and environmental factors and recovery to inform larger future studies.
Who should consider this trial
Good fit: Adults aged 18–55 who have had an acute stroke and can be recruited within one month of the event (or within three months if earlier recruitment was not possible) and who do not have severe progressive illness or major psychiatric conditions.
Not a fit: People with a life expectancy under 24 months, severe progressive neurological disease (e.g., advanced dementia or severe MS), or major psychiatric conditions requiring medical intervention are unlikely to gain direct benefit from this study.
Why it matters
Potential benefit: If successful, this approach could help identify markers and patterns that guide more personalized recovery plans for younger stroke survivors.
How similar studies have performed: Deep phenotyping has shown promise in other neurological and vascular research, but multicenter deep phenotyping specifically focused on young stroke survivors is limited and largely exploratory.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Between 18 and 55 years. 2. Within one month of acute stroke confirmed with standard of care brain imaging or clinical diagnosis or for those for whom recruitment \<1 month of stroke is not possible they may be recruited to participate within 3-months of stroke Exclusion Criteria: 1. Severe, intercurrent or progressive illness likely to EITHER 1. Have a prognosis for survival under 24 months; OR 2. In the opinion of the investigator will mask the importance to the individual participant data (e.g. severe MS, dementia, etc) 2. Major psychiatric condition requiring medical intervention
Where this trial is running
Heidelberg, Victoria and 1 other locations
- Austin Health — Heidelberg, Victoria, Australia (RECRUITING)
- Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre — Heidelberg, Victoria, Australia (NOT_YET_RECRUITING)
Study contacts
- Principal investigator: Vincent Thijs, MD, PhD — Florey Institute of Neuroscience and Mental Health
- Study coordinator: Emily Ramage, BPhysio, PhD
- Email: emily.ramage@florey.edu.au
- Phone: +61 3 90357000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Stroke Patients, Stroke, Sequelae, Young Adults, recovery, young stroke, ischemic stroke, hemorrhagic stroke