Deep phenotyping to explore recovery in young adults after stroke
Official title: Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke
Run by The Florey Institute of Neuroscience and Mental Health · NCT07019493 · Data updated 2026-11-12
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | The Florey Institute of Neuroscience and Mental Health Academic / other |
| Locations | 2 sites (Heidelberg, Victoria and 1 other locations) |
| Status | Recruiting |
| Started | July 19, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 2027 |
| Registry record updated | April 21, 2026 |
| Trial ID | NCT07019493 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–55 who have had an acute stroke and can be recruited within one month of the event (or within three months if earlier recruitment was not possible) and who do not have severe progressive illness or major psychiatric conditions.
✕Probably not a fit
People with a life expectancy under 24 months, severe progressive neurological disease (e.g., advanced dementia or severe MS), or major psychiatric conditions requiring medical intervention are unlikely to gain direct benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a small, observational pilot across Melbourne hospitals enrolling up to 100 young adults with recent stroke. Participants undergo comprehensive data collection and biological sampling to create a detailed picture of their health and recovery. The study will measure feasibility outcomes such as practicality, consistency, and participant acceptability of the deep phenotyping protocol. Investigators will also explore relationships between biomarkers, demographics (age, sex), stroke type, lifestyle and environmental factors and recovery to inform larger future studies.
Why it matters
Potential benefit: If successful, this approach could help identify markers and patterns that guide more personalized recovery plans for younger stroke survivors.
How similar studies have gone: Deep phenotyping has shown promise in other neurological and vascular research, but multicenter deep phenotyping specifically focused on young stroke survivors is limited and largely exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Between 18 and 55 years. 2. Within one month of acute stroke confirmed with standard of care brain imaging or clinical diagnosis or for those for whom recruitment \<1 month of stroke is not possible they may be recruited to participate within 3-months of stroke Exclusion Criteria: 1. Severe, intercurrent or progressive illness likely to EITHER 1. Have a prognosis for survival under 24 months; OR 2. In the opinion of the investigator will mask the importance to the individual participant data (e.g. severe MS, dementia, etc) 2. Major psychiatric condition requiring medical intervention
Where it's running
-
Austin Health
Heidelberg, Victoria, Australia Recruiting -
Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre
Heidelberg, Victoria, Australia Not yet recruiting
Study contacts
- Principal investigator: Vincent Thijs, MD, PhD — The Florey Institute of Neuroscience and Mental Health
- Study coordinator: Emily Ramage, BPhysio, PhD
- Email: emily.ramage@florey.edu.au
- Phone: +61 3 90357000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
-
Personalized exercise program to improve walking in stroke patients
This study tests if a personalized exercise program can help stroke patients improve their walking and balance better than a standard exercise routine.
-
Feasibility of a home-based physiotherapy program with telerehabilitation after stroke
A 16-week home-based physiotherapy program with tele-rehab is being tested to see if it can help stroke survivors do more therapy and improve motor function.
-
Using patterned non-invasive brain stimulation (iTBS) to improve hand strength after chronic stroke
This trial will test whether a high-dose patterned non-invasive brain stimulation (iTBS) can help people with chronic stroke regain hand muscle strength and motor control.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Web-based therapy using action observation and mirror therapy for arm weakness after stroke
This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.