Web-based therapy using action observation and mirror therapy for arm weakness after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, assessor-blinded randomized trial compares two mobile health-based rehabilitation approaches for the upper limb after subacute stroke. Participants with unilateral hemiparesis, 1–6 months post-stroke, and moderate impairment will be randomized to either AOT alone or AOT combined with mirror therapy using the Neuro-Mirror Pro app. The program includes standardized 12-movement modules and privacy-conscious real-time mirror illusions, with adherence tracking and no cloud transfer of raw video. Outcomes will focus on motor recovery and functional ability of the affected arm. The study aims to determine if adding mirror therapy to action observation provides added benefit in a telerehabilitation setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged between 20 and 80 years.
2. First-ever unilateral hemispheric or brainstem stroke confirmed by neuroimaging (brain CT or MRI).
3. Subacute stroke stage, defined as stroke onset between 1 and 6 months prior to study enrollment.
4. Baseline Fugl-Meyer Assessment for Upper Extremity (FMA-UE) score between 20 and 60, indicating moderate to mild-moderate upper limb motor impairment.
5. Preserved cognitive function sufficient to understand and follow verbal instructions, with the ability to operate a smartphone or touch-screen mobile device.

Exclusion Criteria:

1. Diagnosis of global aphasia or severe receptive aphasia that precludes basic verbal communication or comprehension of study tasks.
2. Presence of severe hemispatial neglect.
3. Coexisting significant medical conditions or musculoskeletal disorders that substantially restrict the passive range of motion or active movement of the paretic upper limb.
4. Inability or refusal to use mobile touch-screen devices.

Where it's running

• Chang Gung Memorial Hospital
  Taoyuan, Taiwan Recruiting

Study contacts

• Principal investigator: Chih Chi Chen, M.D. — Chang Gung Memorial Hospital
• Study coordinator: Chih-Chi Chen, M.D.
• Email: claudia5477@gmail.com
• Phone: 001-886-3-3281200

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.