Ultrasound-Guided Injection for Carpal Tunnel Syndrome: Hyaluronic Acid vs Corticosteroid vs 5% Glucose

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This early-phase, randomized comparison will enroll 60 adults with clinically and electrophysiologically confirmed mild to moderate CTS and assign 20 to each injection type. Each participant will receive a single ultrasound-guided injection of either hyaluronic acid, corticosteroid, or 5% glucose and will be evaluated after three months. Assessments will include clinical signs (Phalen's test, Tinel's sign), nerve conduction studies, and ultrasound measurement of the median nerve cross-sectional area. The trial aims to determine relative effectiveness and safety of these injectates in improving symptoms and nerve function. Results will inform whether alternative injections could offer benefits over standard corticosteroid therapy for CTS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults aged 18-70 years. Clinical symptoms of carpal tunnel syndrome for ≥6 weeks. Electrophysiological confirmation of mild to moderate carpal tunnel syndrome. Ability to provide informed consent.

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Exclusion Criteria:

* Prior injection into the same wrist within the previous 6 months. Previous carpal tunnel surgery. Severe carpal tunnel syndrome, defined by absent sensory potentials or electromyographic evidence of denervation.

Local infection or coagulopathy.

Where it's running

• Tanta University Faculty of Medicine
  Tanta, Gharbia Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Nahla ME Mahfouz, Batcholer degree of medicine a
• Email: dr.nahlamahfouz@gmail.com
• Phone: +201279151365

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.