Amniotic Membrane and Secretome Added to Carpal Tunnel Release

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, early-phase study compares standard carpal tunnel release to release with adjunctive amniotic membrane and secretome in adults with moderate-to-severe CTS. Outcomes are measured before surgery and three weeks after using the Boston Carpal Tunnel Questionnaire and electromyography to gauge symptoms, function, and nerve recovery. The design includes a pre- and post-intervention assessment to determine the added benefit of the biological adjuncts. Participants are adults with CTS confirmed by EMG who have not responded to conservative treatment. Key safety and feasibility signals will be monitored as the study explores a potential new option to enhance surgical recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older.
* Diagnosed with moderate-to-severe Carpal Tunnel Syndrome (CTS) based on electromyography (EMG) according to the Bland classification.
* Persistent CTS symptoms that have not improved with conservative treatment.
* Willing and able to provide written informed consent and comply with study procedures.

Exclusion Criteria:

* Previous carpal tunnel release surgery on the affected wrist.
* History of wrist trauma or previous wrist surgery.
* Presence of comorbidities that may affect nerve healing or study outcomes, including diabetes mellitus, hypertension, or metabolic disorders.
* Symptoms resembling CTS are attributable to other conditions, such as cervical spine or cervical nerve disorders (e.g., cervical radiculopathy).

Where it's running

• Prof. dr. I.G.N.G. Ngoerah General Hospital
  Denpasar, Bali, Indonesia Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ultrasound-Guided Injection for Carpal Tunnel Syndrome: Hyaluronic Acid vs Corticosteroid vs 5% Glucose

  This study tests three ultrasound-guided injections (hyaluronic acid, corticosteroid, and 5% glucose) to see which best helps adults with mild to moderate carpal tunnel syndrome.

  Recruiting Early Phase 1 Tanta University · Tanta, Gharbia Governorate · NCT07825155

• Open vs ultrasound-guided carpal tunnel release ( CTS )

  This study compares two surgical approaches for carpal tunnel syndrome to see which helps people recover better after surgery.

  Recruiting at 2 sites AUVA General Trauma Hospital Salzburg · Salzburg and 1 other locations · NCT07814547

• Reliability and validity of hand function tests in carpal tunnel syndrome

  This study tests whether three hand function tests (JTHFT, MDT, and Nine-Hole Peg Test) are reliable and valid for people with carpal tunnel syndrome.

  Recruiting Izmir Bakircay University · Izmir · NCT07706296

• Neuromobilization, Tendon Gliding, or Both for Mild to Moderate Carpal Tunnel Syndrome

  This trial tests whether neuromobilization, tendon gliding exercises, or a combination of both help reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome.

  Recruiting Ibadat International University, Islamabad · Islamabad, ICT · NCT07653789

• MeDe: Carpal tunnel release with added lacertus release vs carpal tunnel release alone

  In adults with carpal tunnel syndrome, this trial tests whether adding a lacertus fibrosus release to the standard carpal tunnel release helps reduce symptoms and improve hand function.

  Recruiting at 2 sites Maasstad Hospital · Rotterdam, South Holland and 1 other locations · NCT07594821

• Effect of peripheral repetitive magnetic stimulation on elbow or wrist pain

  This pilot study tests whether two days of active peripheral repetitive magnetic stimulation can reduce pain in adults with tennis/golfer’s elbow or carpal tunnel syndrome, compared with a sham treatment.

  Recruiting University of Manitoba · Winnipeg, Manitoba · NCT07544914

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.