Neuromobilization, Tendon Gliding, or Both for Mild to Moderate Carpal Tunnel Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares three physical therapy approaches for mild to moderate carpal tunnel syndrome: neuromobilization techniques, tendon gliding exercises, and a combined program. Participants are adults meeting criteria for CTS and are assigned to one of the three intervention groups to see which approach most effectively reduces pain and improves hand function and quality of life. The study aims to provide evidence to guide physiotherapists in selecting treatment strategies that optimize outcomes. Results may inform clinical guidelines for non-surgical management of CTS. The trial is conducted at a single center in Islamabad with a lead sponsor from Ibadat International University.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • Symptoms of CTS (pain, paresthesia in the area of hand innervated by the median nerve)

  * First and Second Trimester Pregnant women.
  * Mild to Moderate CTS patients.
  * Individuals experiencing wrist pain for a duration of at least 6-8 weeks without a history of trauma or specific diagnosis (e.g., fracture, arthritis).
  * Pain rated between 3 and 5 on (NPRS).
  * Present neurological disorders (e.g., carpal tunnel syndrome, cervical radiculopathy).
  * No prior physical therapy treatment for wrist pain in the last 3-6 months

Exclusion Criteria:

* • History of traumatic injury, fracture, or surgery to the wrist or hand.

  * Diagnosis of systemic diseases affecting the wrist (e.g., rheumatoid arthritis, gout, or diabetes-related neuropathy).
  * Any skin condition or infection around the wrist that would contraindicate physical therapy.
  * Third Trimester Pregnant women
  * Individuals with serious cardiovascular or metabolic disorders.
  * patients currently undergoing other treatments specifically targeting CTS (e.g., steroid injections)

Where it's running

• Dr. Akbar Niazi teaching Hospital
  Islamabad, Ict, Pakistan Recruiting

Study contacts

• Study coordinator: Gul Asheen, DPT, MSPT MSK
• Email: gulafsheen123@gmail.com
• Phone: +923435776966

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ultrasound-Guided Injection for Carpal Tunnel Syndrome: Hyaluronic Acid vs Corticosteroid vs 5% Glucose

  This study tests three ultrasound-guided injections (hyaluronic acid, corticosteroid, and 5% glucose) to see which best helps adults with mild to moderate carpal tunnel syndrome.

  Recruiting Early Phase 1 Tanta University · Tanta, Gharbia Governorate · NCT07825155

• Open vs ultrasound-guided carpal tunnel release ( CTS )

  This study compares two surgical approaches for carpal tunnel syndrome to see which helps people recover better after surgery.

  Recruiting at 2 sites AUVA General Trauma Hospital Salzburg · Salzburg and 1 other locations · NCT07814547

• Amniotic Membrane and Secretome Added to Carpal Tunnel Release

  This trial tests whether adding amniotic membrane and secretome to carpal tunnel surgery helps people with moderate-to-severe CTS recover better than surgery alone.

  Recruiting Early Phase 1 PT. Prodia Stem Cell Indonesia · Denpasar, Bali · NCT07723313

• Reliability and validity of hand function tests in carpal tunnel syndrome

  This study tests whether three hand function tests (JTHFT, MDT, and Nine-Hole Peg Test) are reliable and valid for people with carpal tunnel syndrome.

  Recruiting Izmir Bakircay University · Izmir · NCT07706296

• MeDe: Carpal tunnel release with added lacertus release vs carpal tunnel release alone

  In adults with carpal tunnel syndrome, this trial tests whether adding a lacertus fibrosus release to the standard carpal tunnel release helps reduce symptoms and improve hand function.

  Recruiting at 2 sites Maasstad Hospital · Rotterdam, South Holland and 1 other locations · NCT07594821

• Effect of peripheral repetitive magnetic stimulation on elbow or wrist pain

  This pilot study tests whether two days of active peripheral repetitive magnetic stimulation can reduce pain in adults with tennis/golfer’s elbow or carpal tunnel syndrome, compared with a sham treatment.

  Recruiting University of Manitoba · Winnipeg, Manitoba · NCT07544914

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.