MeDe: Carpal tunnel release with added lacertus release vs carpal tunnel release alone

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial compares two surgical approaches for CTS: releasing only the carpal tunnel versus releasing both the carpal tunnel and the lacertus fibrosus. It targets adults with CTS confirmed by EMG or nerve ultrasound. Outcomes will come from patient-reported symptoms and function after surgery, aiming to see if the extended release provides additional relief for those whose proximal nerve compression may contribute to ongoing symptoms. The study addresses a gap where proximal compression is hard to detect with standard tests, potentially guiding more comprehensive surgical care. Participating centers are Maasstad Hospital in Rotterdam and Spijkenise Medisch Centrum, with adults 18+ who choose surgical treatment and meet eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients being at least 18 years or older
* CTS confirmed by EMG or nerve ultrasound
* Patient opts for surgical treatment

Exclusion Criteria:

* Previous surgical decompression of the median nerve at the ipsilateral wrist or forearm
* Severe thenar atrophy: Examination of the thenar is based on clinical observation. The presence of thenar muscle atrophy is scored as none, mild, or severe.
* Simultaneous nerve decompression in the ipsilateral arm (e.g. cubital tunnel, Guyon and radial nerve release.
* Neurological disorders affecting peripheral nerves (e.g. spinal cord compression or injury, muscular dystrophy, dystonia, ALS)
* Malunion of the distal radius
* Impaired hand function
* Pregnancy
* Inability to complete study forms due to insufficient comprehension of the Dutch language

Where it's running

• Maasstad Ziekenhuis
  Rotterdam, South Holland, Netherlands Recruiting
• Spijkenise Medisch Centrum
  Rotterdam, South Holland, Netherlands Recruiting

Study contacts

• Study coordinator: Sebastian Poggio Voormolen, BSc, PhD candidate
• Email: PoggioVoormolenS@maasstadziekenhuis.nl
• Phone: +31 6 46560865

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ultrasound-Guided Injection for Carpal Tunnel Syndrome: Hyaluronic Acid vs Corticosteroid vs 5% Glucose

  This study tests three ultrasound-guided injections (hyaluronic acid, corticosteroid, and 5% glucose) to see which best helps adults with mild to moderate carpal tunnel syndrome.

  Recruiting Early Phase 1 Tanta University · Tanta, Gharbia Governorate · NCT07825155

• Open vs ultrasound-guided carpal tunnel release ( CTS )

  This study compares two surgical approaches for carpal tunnel syndrome to see which helps people recover better after surgery.

  Recruiting at 2 sites AUVA General Trauma Hospital Salzburg · Salzburg and 1 other locations · NCT07814547

• Amniotic Membrane and Secretome Added to Carpal Tunnel Release

  This trial tests whether adding amniotic membrane and secretome to carpal tunnel surgery helps people with moderate-to-severe CTS recover better than surgery alone.

  Recruiting Early Phase 1 PT. Prodia Stem Cell Indonesia · Denpasar, Bali · NCT07723313

• Reliability and validity of hand function tests in carpal tunnel syndrome

  This study tests whether three hand function tests (JTHFT, MDT, and Nine-Hole Peg Test) are reliable and valid for people with carpal tunnel syndrome.

  Recruiting Izmir Bakircay University · Izmir · NCT07706296

• Neuromobilization, Tendon Gliding, or Both for Mild to Moderate Carpal Tunnel Syndrome

  This trial tests whether neuromobilization, tendon gliding exercises, or a combination of both help reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome.

  Recruiting Ibadat International University, Islamabad · Islamabad, ICT · NCT07653789

• Effect of peripheral repetitive magnetic stimulation on elbow or wrist pain

  This pilot study tests whether two days of active peripheral repetitive magnetic stimulation can reduce pain in adults with tennis/golfer’s elbow or carpal tunnel syndrome, compared with a sham treatment.

  Recruiting University of Manitoba · Winnipeg, Manitoba · NCT07544914

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.