Two Endoscopic Treatments for Small Rectal Neuroendocrine Tumors
Official title: Retrospective Comparative Study of Two Different Endoscopic Treatments for Rectal Neuroendocrine Neoplasms
Run by Jilin University · NCT07612748 · Data updated 2026-11-12
This study compares two endoscopic techniques to see which safely and effectively treats small rectal neuroendocrine tumors (R-NENs).
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 483 (estimated) |
| Sponsor | Jilin University Academic / other |
| Locations | 2 sites (Changchun, Jilin and 1 other locations) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | November 1, 2026 |
| Study ends | December 1, 2027 |
| Registry record updated | June 3, 2026 |
| Trial ID | NCT07612748 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with rectal neuroendocrine neoplasms measuring less than 2 cm, without lymph node or distant metastasis, suitable for either ESD or EPMR.
✕Probably not a fit
Patients whose tumors are unsuitable for ESD or EPMR, or who have metastases or other exclusion criteria, may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers looked back at patients treated for rectal neuroendocrine neoplasms between 2020 and 2026, comparing endoscopic submucosal dissection (ESD) with endoscopic partial muscle resection (EPMR). They examined lesion number, size, procedure time, complications, margins, staging, lymphovascular invasion, and need for additional therapy to determine which method yields better outcomes. The analysis aimed to identify the optimal approach for endoscopic treatment of R-NENs smaller than 2 cm without metastasis. No randomization was performed; findings reflect retrospective experience from a single center. Results could guide future choices in endoscopic therapy for these tumors.
Why it matters
Potential benefit: If successful, patients may receive a clearer, safer endoscopic option tailored to small rectal neuroendocrine tumors.
How similar studies have gone: Prior research suggests endoscopic techniques can be effective for small rectal neuroendocrine tumors, but direct head-to-head comparisons like this are relatively limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing endoscopic treatment for rectal neuroendocrine neoplasms. * Lesion diameter less than 2 cm. * Preoperative auxiliary examinations indicating no peripheral lymph node or distant metastasis. * Endoscopic surgical approach limited to ESD or EPMR. Exclusion Criteria: * Use of non-ESD or non-EPMR endoscopic techniques, such as ligation-assisted resection or Endoscopic Mucosal Resection (EMR). * Presence of other conditions deemed by the investigator to be unsuitable for participation in this study. * Patient or family refusal to participate.
Where it's running
-
the First Hospital of Jilin University
Changchun, Jilin, China Recruiting -
the First Hospital of Jilin University
Changchun, China Active not recruiting
Study contacts
- Study coordinator: Dong Yang, Doctor
- Email: yang_dong@jlu.edu.cn
- Phone: 86-18844097668
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.