Where Helicobacter pylori is found across different stages of stomach atrophy and early stomach cancer
Official title: Distribution Characteristics of Helicobacter Pylori in Different Gastritis and Early Gastric Cancer States Using Immunohistochemical Staining
Run by Jilin University · NCT07253948 · Data updated 2026-11-12
This study tests whether the pattern and amount of H. pylori on stomach biopsy samples differ across stages of atrophic gastritis and early gastric cancer to help guide earlier screening.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 231 (estimated) |
| Sponsor | Jilin University Academic / other |
| Locations | 1 site (Changchun, Jilin) |
| Status | Recruiting |
| Started | October 22, 2025 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | November 28, 2025 |
| Trial ID | NCT07253948 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 who had positive H. pylori immunohistochemical testing at the First Hospital of Jilin University with adequate biopsies from both the greater and lesser curvatures of the antrum and body.
✕Probably not a fit
Patients with prior stomach surgery, suspected autoimmune gastritis, liver cirrhosis, severe comorbidities (such as advanced cancer or renal failure), advanced gastric cancer or gastric lymphoma, or inadequate biopsy sampling are unlikely to be included or benefit from these findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a retrospective analysis of gastric biopsy cases that underwent H. pylori immunohistochemical staining at the First Hospital of Jilin University from March 1, 2023 to August 15, 2025. Two experienced pathologists independently reviewed IHC results and cases were classified using the Kimura-Takemoto system into non-atrophic versus atrophic and non-open versus open atrophy groups. Cases were also categorized as early gastric cancer or non-cancer based on established endoscopic submucosal dissection (ESD) criteria, and H. pylori positivity was graded by colonization extent. The study compares H. pylori distribution across these subgroups and uses multivariate analysis to identify factors associated with early gastric cancer.
Why it matters
Potential benefit: If successful, the results could help clinicians and pathologists target and time early gastric cancer screening by showing typical H. pylori distribution patterns in precancerous and early cancer stages.
How similar studies have gone: Prior studies have linked H. pylori location and burden to atrophic changes and cancer risk, but detailed IHC-based mapping across defined atrophy stages and strict ESD-based early cancer criteria is relatively uncommon and partially novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age 18-80 years * received H. pylori immunohistochemical testing at our center and tested positive. Exclusion Criteria: * biopsies not collected from both the greater and lesser curvatures of the gastric antrum and body * history of stomach surgery * suspected autoimmune gastritis under endoscopy * liver cirrhosis * severe comorbidities such as advanced cancer or renal failure * advanced gastric cancer or gastric lymphoma
Where it's running
-
the First Hospital of Jilin University
Changchun, Jilin, China Recruiting
Study contacts
- Study coordinator: Dong Yang, Doctor
- Email: 714488468@qq.com
- Phone: 86-18844097668
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
H. pylori status and tissue features to predict gastric cancer behavior after endoscopic treatment
This study tests whether current H. pylori infection status and tissue features can help predict how early gastric cancer will behave after endoscopic treatment.
-
SPADE procedure for upper stomach cancer
A multicenter study will test the SPADE operation, a special stomach reconnection technique, in patients with early upper-stomach cancer undergoing proximal gastrectomy to see if it is safe and feasible.
-
LECS with sentinel node navigation for early gastric cancer
This study tests whether combining LECS with sentinel node navigation can treat early gastric cancer while preserving stomach function in eligible patients.
-
Image-guided platform helps find sentinel lymph nodes in early gastric cancer
This study tests whether an image-guided platform with a deep learning model can find and retrieve sentinel lymph nodes better than standard palpation in people with early gastric cancer undergoing LECS-SNNS.
-
Early Gastric Cancer in China: Real-World Outcomes by Treatment Type
This project will look at real-world outcomes for about 5,000 Chinese patients with early gastric cancer treated with endoscopic resection, laparoscopic surgery, open surgery, or a combined approach to see how treatments relate to survival and recurrence.
-
Dual-endoscope Sentinel Lymph Node Navigation for Early Gastric Cancer
This study tests whether using two endoscopes to guide sentinel lymph node navigation during laparoscopic surgery is safe and effective for people with early gastric cancer who need additional surgery after initial endoscopic treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.