Ten modern techniques for full-thickness macular hole repair compared

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, randomized study assigns eligible adults with full-thickness macular holes to one of ten PPV-based surgical techniques, with stratification by hole size. Surgeons perform the procedures during pars plana vitrectomy and standardized postoperative care is followed. Key outcomes include anatomical hole closure on OCT and visual acuity, assessed at Day 7, Month 1, and Year 1, along with safety and reoperation rates. The trial also evaluates adjuncts like autologous PRP and human amniotic membrane grafts as part of the interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults aged ≥18 years.

Full-thickness macular hole (FTMH) eligible for pars plana vitrectomy (PPV).

Symptom duration ≤12 months.

Clear ocular media sufficient for high-quality OCT imaging.

No prior pars plana vitrectomy in the study eye.

No severe foveal atrophy on OCT.

Able and willing to comply with postoperative positioning and follow-up visits.

Written informed consent provided.

Exclusion Criteria:

A. Etiology-Related / Secondary Macular Holes:

Traumatic macular hole.

High myopia with posterior staphyloma (axial length \>28 mm and/or spherical equivalent ≤-8.0 D).

Diabetic tractional retinal detachment (TRD) or significant tractional maculopathy.

Retinal vascular occlusion-related macular hole.

Uveitis-related macular hole.

Advanced age-related macular degeneration (AMD) with foveal atrophy.

B. Prior Interventions:

Any prior pars plana vitrectomy in the study eye.

C. Ocular Conditions That May Affect Outcomes or Safety:

Active or recent ocular infection or inflammation (e.g., uveitis, endophthalmitis, keratitis).

Uncontrolled glaucoma (intraocular pressure \>28 mmHg despite treatment).

Media opacity precluding adequate OCT (e.g., dense cataract or corneal opacity).

Geographic atrophy involving the fovea.

Where it's running

• Kazakh Eye Research Institute
  Almaty, Almaty, Kazakhstan Recruiting

Study contacts

• Principal investigator: Sanzhar Sambet Sambet, MD — Kazakh Eye Research Institute
• Study coordinator: Sanzhar Sambet, MD
• Email: sanzhrs@gmail.com
• Phone: +77758719834

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.