Clinical trial Recruiting at 4 sites Interventional Ages 40 to 70

Comparison of ACUVUE OASYS MAX 1-Day Multifocal vs DAILIES AquaComfort Plus Multifocal

Official title: Comparison of ACUVUE® OASYS MAX 1-Day Multifocal and DAILIES® AquaComfort Plus® Multifocal

Run by Johnson & Johnson Vision Care, Inc. · NCT07788521 · Data updated 2026-11-12

This study tests two daily multifocal contact lenses in adults 40–70 to see which provides better vision and comfort while wearing them regularly.

More Visual Acuity trials

Quick facts

Study typeInterventional
Ages40 Years to 70 Years
SexAll
Enrollment150 (estimated)
SponsorJohnson & Johnson Vision Care, Inc.
Industry-sponsored
Locations11 sites (Longwood, Florida and 10 other locations)
StatusRecruiting
StartedSeptember 10, 2026
Main results expectedDecember 11, 2026
Study endsDecember 11, 2026
Registry record updatedNovember 6, 2026
Trial IDNCT07788521 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 40–70 who wear soft presbyopic contact lenses in both eyes and can adhere to the study protocol.

Probably not a fit

Individuals who do not experience improved vision or comfort with either lens, or who do not meet the refractive criteria, may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multi-site, randomized, single-masked, parallel-group clinical trial comparing two multifocal contact lenses. Eligible participants are soft contact lens wearers aged 40 to 70 who are presbyopic or using presbyopic correction. Each participant will be dispensed either the test lens or the control lens and followed across four visits to assess safety and efficacy of vision and lens performance. The trial uses senofilcon A and nelfilcon A as the materials under comparison and is conducted at three U.S. sites. The study design aims to provide evidence on how the lenses perform in real-world wearing conditions over time.

Why it matters

Potential benefit: If successful, participants may experience improved visual performance and comfort with the test lens compared with the control lens.

How similar studies have gone: Previous research has evaluated similar multifocal lenses with mixed but informative outcomes regarding vision performance and comfort.

Who can join: the full rules

Show full inclusion / exclusion criteria
Potential subjects must satisfy all of the following criteria to be enrolled in the study:

1. Read, understand, and sign the STATEMENT OF INFORMED CONSENT and receive a fully executed copy of the form.
2. Appear able and willing to adhere to the instructions set forth in this clinical protocol.
3. Be at least 40 years of age and not greater than 70 years of age at the time of consent.
4. Own a wearable pair of spectacles if required for their distance vision.
5. Be an adapted soft contact lens wearer in both eyes (i.e. worn lenses a minimum of 2 days per week for at least 6 hours per wear day, for 30 days or more duration).
6. Either already be wearing a presbyopic contact lens correction (e.g., reading spectacles over contact lenses, multifocal or monovision contact lenses, etc.) or if not respond positively to at least one symptom on the "Presbyopic Symptoms Questionnaire".
7. The subject's distance spherical equivalent refraction (vertex corrected if ≥-4.25 D) must be in the range of -1.50 D to -5.50 D in each eye.
8. The subject's refractive cylinder must be ≤0.75 D in each eye.
9. The subject's ADD power must be in the range of +0.75 D to +2.50 D.
10. The subject must have distance best corrected visual acuity of 0.0 logMAR (20/20 Snellen, 5.0 on the China standard 5-point logMAR visual acuity scale) or better in each eye.

Potential subjects who meet any of the following criteria will be excluded from participating in the study:

1. Be currently pregnant or lactating.
2. Have any active or ongoing ocular or systemic allergies that may interfere with contact lens wear.
3. Have been diagnosed with diabetes.
4. Have any active or ongoing systemic disease, autoimmune disease, or use of medication, which may interfere with contact lens wear. This may include, but not be limited to, hyperthyroidism, Sjögren's syndrome, xerophthalmia, acne rosacea, Stevens-Johnson syndrome, and immunosuppressive diseases or any infectious diseases (e.g. hepatitis, tuberculosis).
5. Have any previous, or planned, ocular or intraocular surgery (e.g. radial keratotomy, PRK, LASIK, lid procedures, dacryocystorhinostomy, peripheral iridotomy/iridectomy, cataract surgery, retinal surgery, etc.).
6. Have a history of amblyopia, strabismus or binocular vision abnormality.
7. Use of any of the following medications within 1 week prior to enrollment: oral retinoid, oral tetracyclines, anticholinergics, oral phenothiazines, oral/inhaled corticosteroids.
8. Use of any ocular medication.
9. Have a history of herpetic keratitis.
10. Have a history of irregular cornea.
11. Have a history of pathological dry eye.
12. Have a history of glaucoma or glaucoma suspect.
13. Have a history of any retinal disease/condition that may interfere with any of the study assessments or are not stable and have potential to progress during the study.
14. Have participated in any contact lens or lens care product clinical trial within 15 days prior to study enrollment.
15. Be an employee (e.g., Investigator, Coordinator, Technician) or immediate family member of an employee (including partner, child, parent, grandparent, grandchild, sibling of the employee or their spouse) of the clinical site.
16. Have any known hypersensitivity or allergic reaction to sodium fluorescein.
17. Have Grade 3 or greater palpebral conjunctival observations or Grade 2 or greater slit lamp findings (e.g. corneal edema, corneal vascularization, corneal staining, bulbar injection, etc.) on the ISO 11980 classification scale, or any other corneal or ocular abnormalities which would contraindicate contact lens wear.
18. Have any current ocular infection or inflammation.
19. Have intraocular pressure in one or both eyes \>21mmHg
20. Have signs of any retinal disease/conditions that may interfere with any of the study assessments or are not stable and have potential to progress during the study.

Where it's running

  • Spectrum Eyecare
    Jamestown, New York, United States
    Recruiting
  • Center for Ophthalmic and Vision Research/Eye Associates of New York
    Manhattan, New York, United States
    Recruiting
  • Paradigm Research Center, LLC
    Houston, Texas, United States
    Recruiting
  • Botetourt Eyecare, LLC
    Salem, Virginia, United States
    Recruiting
  • Pearson Research Center PA
    Longwood, Florida, United States
    Completed
  • VisualEyes
    Roswell, Georgia, United States
    Active not recruiting
Show 5 more locations
  • The Koetting Associates
    St Louis, Missouri, United States
    Active not recruiting
  • Sacco Eye Group
    Vestal, New York, United States
    Active not recruiting
  • Dr. David W. Ferris & Associates
    Warwick, Rhode Island, United States
    Active not recruiting
  • Total Eye Care
    Memphis, Tennessee, United States
    Completed
  • Tyler Eye Associates
    Tyler, Texas, United States
    Active not recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.