Structured antimicrobial review in ICUs to improve prescribing
Official title: Evidence Based QUality Improvement for Prescribing Stewardship in ICU: Can a Structured Antimicrobial Review be Implemented in LMIC ICUs?
Run by University of Oxford · NCT06666738 · Data updated 2026-11-12
This project tests a structured antimicrobial review in adult ICUs to see if it can be implemented successfully.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 6300 (estimated) |
| Sponsor | University of Oxford Academic / other |
| Locations | 1 site (Hanoi, Hanoi) |
| Status | Recruiting |
| Started | January 13, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | October 7, 2026 |
| Trial ID | NCT06666738 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult ICUs affiliated with the Care Quality Registries that appoint a local champion and record antimicrobial prescriptions.
✕Probably not a fit
ICUs that have already achieved high adoption (>=80%) of structured antimicrobial review may not gain additional benefits.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational effort looks at how a structured antimicrobial review can be put into practice in intensive care units. It uses local protocols, audit and feedback, and education to guide prescriptions, and collects daily process data plus interviews with local champions. The study is funded by the Wellcome Flagship Innovations award and involves collaboration between Oxford and MORU, with sites in Vietnam. Eligibility focuses on ICUs within specific care registries that appoint a champion and provide all antimicrobial prescriptions for adults in those units.
Why it matters
Potential benefit: If successful, ICUs may improve antimicrobial prescribing practices and patient safety through a replicable implementation approach.
How similar studies have gone: Previous implementations of structured antimicrobial review in ICU settings have shown potential for improving prescribing processes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult ICUs within CCAA-affiliated Care Quality Registries * ICUs must appoint a named Champion to facilitate implementation * All antimicrobial prescriptions for adult patients within the ICUs described above Exclusion Criteria: • ICU's which demonstrate adoption and reach of 80% or greater (median over 2 months) of a pre-existing structured antimicrobial review
Where it's running
-
National Hospital for Tropical Diseases
Hanoi, Hanoi, Vietnam Recruiting
Study contacts
- Principal investigator: Abi Beane, Dr. — University of Oxford
- Study coordinator: Duncan Wagstaff, PhD
- Email: d.wagstaff@ucl.ac.uk
- Phone: 0044(0)2076799060
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.