Safer antibiotic use in adult intensive care units

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

SAFE-REDUCE is a hybrid effectiveness-implementation stepped-wedge cluster randomized trial that sequentially introduces an educational quality-improvement intervention to 10 adult ICUs participating in the IMPACTO-MR registry. The intervention combines training for ICU and infection-control teams with ongoing audit-and-feedback based on current antimicrobial and microbiology guidelines. Investigators will use routine IMPACTO-MR data to compare antimicrobial consumption during control and intervention phases and monitor safety outcomes including ICU mortality and length of stay. All adult patients admitted to participating ICUs are included in analyses, with patients under 18 excluded from individual-level analyses.

Why it matters

Who can join: the full rules

Intensive care units inclusion Criteria:

* ICU leadership acceptance to participant in the quality improvement intervention;
* Hospital infection control leadership acceptance to participant in the quality improvement intervention;
* ICU participation in the IMPACTO-MR platform with high quality data;
* ICU potential for quality improvement based on a subjective assessment of the ICU and hospital infection leaderships

Intensive care units exclusion Criteria:

\- Absence of local IRB approval

Participants inclusion Criteria:

* All patients admitted to the intensive care unit

Participants exclusion Criteria:

* Patients younger than 18 years-old will be excluded from individual-level analysis

Where it's running

• Hospital Maternidade São José
  Colatina, Espírito Santo, Brazil Recruiting
• Santa Casa de Misericórdia de Passos
  Passos, Minas Gerais, Brazil Recruiting
• Hospital Municipal de Maringá
  Maringá, Paraná, Brazil Recruiting
• Hospital Pelópidas Silveira
  Recife, Pernambuco, Brazil Recruiting
• Hospital Naval Marcílio Dias
  Rio de Janeiro, Rio de Janeiro, Brazil Recruiting
• Hospital Onofre Lopes
  Natal, Rio Grande do Norte, Brazil Recruiting

Study contacts

• Principal investigator: Bruno A M P Besen, M.D., Ph.D. — Hospital Sirio-Libanes
• Study coordinator: Camila Dietrich
• Email: camila.dietrich@hsl.org.br
• Phone: +55 51 9723-2844

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.