Antibiotic approaches for Stenotrophomonas maltophilia pneumonia in ICU patients
Official title: Antibiotic Treatment for Pneumonia Caused by Stenotrophomonas Maltophilia in ICU Patients
Run by Centre Hospitalier de Saint-Denis · NCT07052604 · Data updated 2026-11-12
This study tests whether using one antibiotic versus two, and whether treating for 7 days versus 14 days, helps adults on ventilators in the ICU with Stenotrophomonas maltophilia pneumonia survive and avoid recurrence.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Centre Hospitalier de Saint-Denis Academic / other |
| Locations | 1 site (Saint-Denis, France) |
| Status | Recruiting |
| Started | December 15, 2023 |
| Main results expected | September 15, 2025 |
| Study ends | September 15, 2025 |
| Registry record updated | July 4, 2025 |
| Trial ID | NCT07052604 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (age 18 or older) who were intubated and mechanically ventilated in the medical ICU at Centre Hospitalier de Saint-Denis between January 1, 2018 and December 31, 2023 with ventilator-associated pneumonia caused by Stenotrophomonas maltophilia.
✕Probably not a fit
Children, non‑ventilated patients, patients with pneumonia caused by other organisms, and anyone who declined use of their data are not included and would not directly benefit from this analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a retrospective observational analysis of adult patients intubated in a medical ICU at Centre Hospitalier de Saint-Denis between January 1, 2018 and December 31, 2023 who had ventilator‑associated pneumonia due to Stenotrophomonas maltophilia. The analysis compares outcomes between patients treated with a single antibacterial agent versus combination therapy and between treatment durations of 7 days versus 14 days. Key outcomes include survival, recurrence of pneumonia, and antibiotic resistance patterns of the isolated bacteria. Findings will be based on chart review and microbiology data from a single center.
Why it matters
Potential benefit: If patterns emerge, the results could help clinicians choose an antibiotic strategy and treatment length that improve survival and reduce recurrence in this difficult-to-treat infection.
How similar studies have gone: Previous evidence on S. maltophilia pneumonia is limited and mainly observational, and there is no definitive randomized evidence that combination therapy or longer treatment duration is superior.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (age ≥ 18 years) * Hospitalized in Medical Intensive Care Unit between January 1, 2018, and December 31, 2023 * Intubated and mechanically ventilated * Diagnosed with ventilator-associated pneumonia caused by Stenotrophomonas maltophilia Exclusion Criteria: * Patients under 18 years old * Patients who refuse the use of their data for research purposes
Where it's running
-
Centre Hospitalier de Saint-Denis
Saint-Denis, France, France Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.