Social Management Training for people with sex chromosome disorders
Official title: A Multiple Baseline Feasibility Trial of Social Management Training for People With Sex Chromosome Aneuploidies
Run by University of Oslo · NCT07718997 · Data updated 2026-11-12
A group-based program of social skills training is tested to see if it helps adults with sex chromosome disorders improve mental health and social skills.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 16 Years to 65 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Oslo Academic / other |
| Locations | 1 site (Oslo) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | September 2029 |
| Study ends | December 2029 |
| Registry record updated | July 22, 2026 |
| Trial ID | NCT07718997 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 16–69 with a genetically confirmed sex chromosome disorder who can participate in online group sessions in Norwegian or a Scandinavian language and have internet access.
✕Probably not a fit
Participants without improvements in social interaction or mental health may not see benefit from the program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study tests Social Management Training delivered online in 10 sessions for adults aged 16–69 with sex chromosome disorders. Using a multiple-baseline design across 6 measurement points over about 30 weeks, it looks at changes in mental health as the main outcome and also tracks social functioning and executive skills. Recruitment is through Norwegian rare-disease networks and clinicians, aiming for 20–30 participants by 2028. The intervention was adapted from prior pilot work to be accessible online and applicable to various SCAs beyond KS. No explicit exclusion criteria are described beyond language and accessibility requirements.
Why it matters
Potential benefit: If successful, participants may experience improved mental health and social functioning.
How similar studies have gone: Previous Dutch pilot work with men with KS showed promising outcomes for SMT, supporting further exploration in a broader SCA population.
Who can join: the full rules
Show full inclusion / exclusion criteria
The inclusion criteria are: (a) Proficiency in a Scandinavian language. Participants must state that they have satisfactory skills to participate in group discussions, and answer questionnaires in Norwegian; (b) Age 16 to 69 years. The age range is set to include adults of the age of consent for participation in health research. The upper age limit was set to prevent measurements from being affected by age-related factors; (c) Access to a computer (or smartphone) with internet connection - but note that we can lend a computer to participants who may require this; (d) Genetically confirmed SCA. Participants provide medical confirmation of diagnosis, unless participants are recruited via Frambu (where medical confirmation is available in the user registry for KS 47,XXY karyotype; Jacobs 47,XYY karyotype; Triple X, 47,XXX karyotype; and Turner 45,X karyotype). There are no explicit exclusion criteria. Ongoing assessments are made during eligibility screening and when conducting training program regarding appropriateness of the training program, both individually and in groups. If the group leader becomes aware of information that indicates the need for specialist health services (e.g., indication of severe mental illness or acute suicidality), this is handled on a case-by-case basis, and the person concerned is then put in contact with the appropriate health care services. \-
Where it's running
-
Oslo University Hospital
Oslo, Norway Recruiting
Study contacts
- Study coordinator: Krister W Fjermestad, PhD
- Email: kristefj@uio.no
- Phone: +4794201947
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Freezing gonadal tissue to help preserve fertility in children with sex development disorders
This study is testing whether freezing and storing gonadal tissue can help children with sex development disorders keep their fertility for the future.
-
Registry to learn about individuals with sex chromosome variations
This study is gathering information from people with sex chromosome variations, like Klinefelter syndrome, to better understand their health and improve their care.
-
Research on health and development in infants with sex chromosome trisomy
This study looks at the health and development of infants with sex chromosome trisomies, like Klinefelter syndrome, to see how they grow and what early signs can help doctors provide better care.
-
Non-invasive fetal cell test to check fetal chromosomal status in early pregnancy
A large, non-invasive blood test in pregnant people between 10 and 20 weeks looks for fetal cells in the mother's blood to see if the baby has certain chromosomal conditions, comparing results to invasive or postnatal diagnoses.
-
Collaboration for Down Syndrome Progress (CDP) in people with Down syndrome
A long-term study following people with Down syndrome of all ages to see how health and everyday life change over time.
-
Observing the health management of patients with rare genetic syndromes
This study looks at how patients with rare genetic syndromes like Prader-Willi and Klinefelter manage their health as they move from children's care to adult care to see what support they need.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.