Freezing gonadal tissue to help preserve fertility in children with sex development disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study offers gonadal tissue freezing and storage for children diagnosed with disorders of sex development (DSD) who are at increased risk of infertility and certain cancers. It involves the removal of gonadal tissue for medical reasons, such as preventing cancer, followed by processing and long-term storage of the tissue. The goal is to potentially use this tissue in the future to help restore reproductive function. The study also aims to research long-term methods for preserving fertility in these children.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individual \< 30 years of age
* Children diagnosed with a disorder of sex development who have any risk for malignancy in their gonadal tissue or will have their gonads removed for another clinical indication

Exclusion Criteria:

* Pregnant children
* Patients likely to retain inherent fertility and reproductive function
* Children deemed high risk for perioperative complications
* Patients 12-18 unable to provide assent (i.e. significant psychiatric problems/cognitive delay)
* Patients 18 and older unable to provide consent (i.e. significant psychiatric problems/cognitive delay)

Where it's running

• Ann & Robert H. Lurie Children's Hospital of Chicago
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Erin Rowell, MD — Ann & Robert H Lurie Children's Hospital of Chicago
• Study coordinator: Sara Reyes
• Email: FertilityPreservation@luriechildrens.org
• Phone: 3122274145

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Identifying genetic causes of growth and puberty disorders

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• Characterization of patients with 46, XY Disorders of Sex Development

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  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna and 3 other locations · NCT06723938

• Collecting data on gynecologic conditions in children and adolescents

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  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04717349

• Freezing gonadal tissue to help preserve fertility in individuals at risk for ovarian dysfunction

  This study is testing if freezing ovarian tissue can help people with conditions like Turner Syndrome and galactosemia preserve their fertility for the future.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04948658

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.