CCTA-Guided CABG vs CAG-Guided CABG

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter pragmatic trial compares two ways of planning coronary artery bypass grafting: using coronary computed tomography angiography (CCTA) versus using coronary angiography (CAG). Participants are randomized to have either planning method guide their CABG, and both groups receive CABG per local protocol. The trial looks at 1-year outcomes including heart attacks, strokes, need for additional procedures, and length of hospital stay, with an internal pilot to assess feasibility and protocol adherence. Primary feasibility outcomes cover screening, consent, randomization, recruitment rate, concordance between planned and actual revascularization, and follow-up completion at 7 and 30 days. The study also explores graft-related outcomes and early morbidity and mortality. Lead sponsor is Ruijin Hospital, with the study conducted at Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Referred to CABG treatment

Exclusion Criteria:

* Under the age of 18 years
* Unable to provide informed consent
* Emergency CABG
* Redo-CABG
* Prior PCI with coronary stent implantation and unable to undergo photon counting CCTA.
* Cardiogenic shock
* Unable to undergo CAG or CCTA examination or deemed unsuitable by the investigator, such as:

Known allergy to iodinated contrast media; Active hyperthyroidism or uncontrolled thyroid disease; Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m²; Atrial fibrillation with rapid ventricular response or severe arrhythmias not amenable to rate control;

* Pregnancy, lactation, or childbearing potential without effective contraception in female participants
* Concurrent participation in another interventional trial

Where it's running

• Ruijin Hospital Shanghai Jiao Tong University School of Medicine
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Yunpeng Zhu, MD
• Email: zyp12220@rjh.com.cn
• Phone: 0086-02164370045

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.