Semaglutide improves fertility and metabolic health in obese women with PCOS
Official title: Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome: a Prospective, Randomized, Open, Controlled Study
Run by Peking University First Hospital · NCT05702905 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if a medication called semaglutide can help obese women with PCOS lose weight and improve their chances of getting pregnant.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 22 Years to 40 Years |
| Sex | Women only |
| Enrollment | 75 (estimated) |
| Sponsor | Peking University First Hospital Academic / other |
| Locations | 1 site (Peking, Beijing) |
| Trial ID | NCT05702905 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are obese infertile women aged 22-40 who meet the diagnostic criteria for PCOS.
✕Probably not a fit
Patients with severe endometriosis, low ovarian reserve, or those unable to tolerate pregnancy and ovulation induction therapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of semaglutide in treating obese infertile women aged 22-40 with polycystic ovary syndrome (PCOS). A total of 75 participants will be randomly assigned to receive either metformin, semaglutide, or a combination of both, alongside a calorie-restricted diet and physical exercise for 12 weeks. The primary focus is on weight loss percentage, while secondary outcomes include metabolic markers, ovulation rates, and pregnancy outcomes over a 24-week follow-up period. The study aims to provide insights into how these treatments can improve fertility and metabolic health in this population.
Why it matters
Potential benefit: If successful, this study could enhance fertility and metabolic health in obese women suffering from PCOS.
How similar studies have gone: Other studies have shown promise in using similar approaches for managing PCOS and improving fertility outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Meet the PCOS diagnostic criteria (Rotterdam） 2. Age 22-40 3. BMI ≥ 28 kg/m2 4. Infertility: having normal sexual life and failing to conceive without contraception for more than 1 year 5. Willing to be pregnant, and her husband has no serious infertility Exclusion Criteria: 1. History of acute pancreatitis, individual or family history of medullary thyroid cancer and multiple endocrine adenomas 2. Type 1 diabetes and special type diabetes 3. History of tumor 4. Serious cardiovascular and cerebrovascular disease, mental disease, liver or kidney disease 5. Metformin, GLP-1 RA and other drugs affecting reproductive and metabolic functions were used within 90 days before the study 6. Known allergy to metformin, GLP-1 RA and excipients 7. Severe endometriosis, low ovarian reserve, premature ovarian failure 8. Inability to tolerate pregnancy and ovulation induction therapy 9. Other conditions considered unsuitable for this study by researchers
Where it's running
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PekingUFH
Peking, Beijing, China Recruiting
Study contacts
- Principal investigator: Tingting Zhang, M.D. — Peking University First Hospital
- Study coordinator: Tingting Zhang, M.D.
- Email: cathine@sina.com
- Phone: 86-10-83575103
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Ovarian drilling via vNOTES laparoscopy for PCOS patients
This study tests whether drilling the ovaries using vNOTES laparoscopy can help women with PCOS who did not respond to first-line medicines.
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PMOS and Sleep Apnea: A Pilot Look at Mitochondrial Function
In women with PMOS, this pilot study tests whether sleep apnea treatment with CPAP improves mitochondrial function in leg muscle tissue.
-
Lean Beef as Part of a Healthy Meal Plan for Adolescent Girls with PCOS/PMOS
This pilot study tests a lean beef–based meal plan to see if it improves blood sugar control and diet quality in adolescent girls with PCOS/PMOS.
-
Inositol and Metformin with Mediterranean or Low-Carb Diets in Women with PCOS
This trial tests whether adding inositol, metformin, or folic acid to either a Mediterranean or a low-carbohydrate diet helps women with PCOS and insulin resistance lose weight and improve metabolic markers.
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Fecal microbiota transplantation for overweight women with PMOS undergoing embryo transfer
We are testing if oral FMT capsules are safe and can improve pregnancy outcomes for overweight/obese women with PMOS undergoing frozen embryo transfer.
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Glp-1/FGF21 dual agonist for PCOS treatment
This study tests a GLP-1/FGF21 dual agonist to see if it helps women with PCOS by improving weight, hormones, and menstrual health.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.