HPV self-sampling in the ED to screen under-screened women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot feasibility trial evaluates implementing HPV self-collection as a primary cervical cancer screening method for women aged 30-65 who are overdue for screening and present to the ED with non-critical illness. Participants receive education and an HPV self-sampling kit to complete in the ED, with immediate return of the specimen. Those who test positive for HPV are navigated to follow-up care at local clinics according to standard guidelines, aiming to reduce barriers to screening for women not regularly using primary care. The study hypothesizes that in-ED distribution and same-day kit return will reduce participant burden compared with mailed self-sampling approaches. The initiative is led by Rutgers with sites at two New Jersey hospitals and targets increasing access to cervical screening in under-screened populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* biological women,
* no prior hysterectomy or cervical cancer,
* not pregnant,
* last Pap \>3 years, last co-test \>5 years, or last HPV alone test \>5 years,
* speak English or Spanish,
* has a working cellphone,
* NJ residency
* ED patient

Exclusion Criteria:

* currently pregnant (as diagnostic procedures for cervical cancer are often deferred during pregnancy);
* previous hysterectomy;
* previous diagnosis of cervical cancer;
* current menses

Where it's running

• Robert Wood Johnson University Hospital
  New Brunswick, New Jersey, United States Recruiting
• University Hospital
  Newark, New Jersey, United States Not yet recruiting

Study contacts

• Principal investigator: Sara Heinert, PhD, MPH — Department of Emergency Medicine, Rutgers Robert Wood Johnson Medical School
• Study coordinator: Sara Heinert, PhD, MPH
• Email: sara.heinert@rutgers.edu
• Phone: (732) 235-7872

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Risk of cervical cancer after HPV detection in healthy women

  This study tests how likely it is for cervical cancer to develop after different HPV detection patterns in healthy women who undergo HPV-based screening.

  Recruiting Karolinska Institutet · Stockholm · NCT07850128

• Routine shallow-coverage Whole Genome Sequencing of Cervical Smears to See if Ovarian Cancer is Found Earlier

  Researchers test whether analyzing DNA from cervical smears with shallow whole-genome sequencing can help detect high-grade serous ovarian cancer early in patients undergoing treatment for this cancer.

  Recruiting Institut Claudius Regaud · Toulouse · NCT07821879

• Low-cost HPV test that gives same-day results and treatment in women 30-59

  A low-cost HPV test done on the same day as a self-collected sample is being tested to see if it can reliably screen for cervical cancer and enable immediate treatment in women aged 30-59 in San Salvador.

  Recruiting The Cleveland Clinic · San Salvador, Oriente · NCT07538050

• Self-sampling HPV screening offered in the emergency department

  This project tests whether offering HPV self-sampling in the emergency department helps more people aged 30–65 with a cervix get screened for cervical cancer.

  Recruiting University of Rochester · Rochester, New York · NCT07345897

• CHW4CervixHealth: HPV self-collection kits with community health workers

  This project will test whether giving self-collection HPV kits during community workshops led by community health workers helps increase screening among under-screened women aged 25–65 and will first compare kit results to clinical Pap smears.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07336134

• Audit of cervical cancer chemoradiation guideline compliance across National Cancer Grid centers

  This project will check how closely hospitals across India follow recommended chemoradiation treatments for patients with cervical cancer.

  Recruiting at 2 sites Tata Memorial Hospital · Mumbai, Maharashtra and 1 other locations · NCT07290972

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.