Effects of a sleep medication on cravings and stress in stimulant use disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of suvorexant, a medication that targets orexin receptors, on sleep quality, stress levels, and drug cravings in individuals undergoing early abstinence from stimulant use disorder. Participants will be compared between those receiving suvorexant and those receiving standard treatment. The study aims to assess how this intervention affects the length of stay and completion rates in a residential treatment program over a 30-day period following treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Meet Diagnostic and Statistical Manual of Mental Disorders(DSM-5)criteria for primary stimulant use disorder (either cocaine or methamphetamine)
* Be fluent in English and able to understand the consent form

Exclusion Criteria:

* Have an opioid use disorder of any severity
* Have a greater than moderate substance use disorder on any other substance
* Undergoing medication-assisted treatment for withdrawal of any substance
* Have any medical conditions contraindicating SUVO (e.g., severe pulmonary disease, severe cardiovascular disease or clinically abnormal ECG, severe liver or kidney disease, seizure disorder, or sleep disorder -particularly narcolepsy)
* Are currently taking medications with known drug interactions with SUVO (e.g., Monoamine oxidase (MAO) inhibitors, anticonvulsants, haloperidol, phenothiazines, anesthetics, and any sedative)
* Are pregnant or breast feeding
* BMI \> 30 (women only)
* Have a current DSM-5 psychiatric disorder or neurological disease requiring on-going treatment that would make participation unsafe
* Have history of seizure disorder
* Have a head injury with loss of consciousness in the last 5 years

Where it's running

• The University of Texas Health Science Center at Houston
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Heather Webber, PhD — The University of Texas Health Science Center, Houston
• Study coordinator: Heather Webber, PhD
• Email: Heather.E.Webber@uth.tmc.edu
• Phone: 713-486-2723

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• DynamiCare-based program to support re-entry for stimulant users at risk for HIV

  This study tests whether adding the DynamiCare mobile app plus patient navigation helps people released from justice settings who use stimulants to start HIV care (ART/PrEP) and reduce stimulant use.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · New Haven, Connecticut and 1 other locations · NCT07136363

• Repetitive Transcranial Magnetic Stimulation for Stimulant Use Disorder in Veterans

  A randomized, placebo-controlled test to see if rTMS helps veterans with stimulant use disorder see reduced use and improved outcomes.

  Recruiting VA Office of Research and Development · Palo Alto, California · NCT07112105

• Smartphone support for stimulant use disorder

  This program will test whether two different smartphone app services can help adults with stimulant use disorder (cocaine, crack, or meth) reduce use and need for medical care while using the apps at home.

  Recruiting DynamiCare Health · Boston, Massachusetts · NCT07092059

• Optimizing brain stimulation techniques for stimulant use disorder

  This study is testing different brain stimulation techniques to see if they can help adults with stimulant use disorder who have recently stopped using drugs.

  Recruiting Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06790576

• Integrated care for hospitalized patients with opioid and stimulant use disorders and infections

  This study tests if a new combined care approach for patients with infections from using opioids or stimulants can help them stay healthier and avoid going back to the hospital compared to regular treatment.

  Recruiting at 4 sites University of Maryland, Baltimore · Washington D.C., District of Columbia and 3 other locations · NCT06513156

• Using Mirtazapine to treat methamphetamine use in patients with opioid use disorder

  This study is testing if the medication Mirtazapine can help people with opioid use disorder reduce their methamphetamine use while they receive standard treatment.

  Recruiting Phase 2 Washington State University · Spokane, Washington · NCT06323837

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.