QFR-Guided Heart Revascularization Quality Registry in CAD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, multicenter observational registry enrolling over 10,000 patients from more than 50 centers in China who have at least one main-branch coronary stenosis of 50% or more. Images from coronary angiography, and intracoronary imaging if available, will be collected and analyzed retrospectively by an independent core laboratory to establish a QFR-based quality control standard for revascularization. Subgroup analyses will explore how concordance between clinical decisions and QFR results varies by hospital level, presentation, disease complexity, lesion characteristics, operator volume, and image quality. The primary endpoint is the accessibility of QFR, represented by the mean usage proportion across centers. The study will include adults with acute or chronic coronary syndromes and will follow participants as per observational registry norms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Coronary angiography showing visually estimated at least one main branch coronary stenosis ≥50% in patients with acute coronary syndrome (including unstable angina, non-ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction \>4 weeks after onset) or chronic coronary syndrome (including stable angina and asymptomatic myocardial ischemia) who undergo PCI or receive conservative treatment
* Ability to understand the study design and provide written informed consent

Exclusion Criteria:

* ST-segment elevation myocardial infarction within 4 weeks of onset
* History of coronary artery bypass grafting (CABG) or planned CABG within 6 months
* Inability to undergo coronary angiography
* Non-cardiac cause with expected survival \<1 year
* Other conditions that may interfere with follow-up (e.g., dementia, substance abuse including drug addiction and other drug dependencies)
* Refusal to participate in the study

Where it's running

• National Clinical Research Center of Cardiovascular Diseases, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Jie Qian, PhD
• Email: qianjfw@163.com
• Phone: 010-88396089

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.