Intraoperative Pulse Pressure Variation and Postoperative Lactate Clearance in CABG Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort at Gaziantep University Hospital involving adults undergoing elective CABG. Researchers will record intraoperative pulse pressure variation (PPV) and measure lactate levels at ICU admission and at 6 and 12 hours after surgery. They aim to see if PPV correlates with lactate clearance postoperatively, using data collected as part of routine care. No extra interventions are performed beyond standard clinical management. Patients with conditions that affect PPV reliability or with incomplete data are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-80 years.
* Patients undergoing elective coronary artery bypass graft (CABG) surgery.
* Patients receiving invasive arterial blood pressure monitoring and mechanical -ventilation during surgery.
* Patients planned for postoperative admission to the intensive care unit.
* Patients whose informed consent has been obtained.

Exclusion Criteria:

* Patients with cardiac arrhythmias that may interfere with PPV measurement, such as atrial fibrillation.
* Patients with severe aortic regurgitation.
* Patients undergoing emergency cardiac surgery.
* Patients receiving off-pump CABG.
* Patients requiring spontaneous breathing or low tidal volume ventilation (\<6 mL/kg) during PPV measurement.
* Patients with missing or insufficient intraoperative hemodynamic or postoperative lactate measurements.

Where it's running

• Gaziantep University Hospital
  Gaziantep, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Elzem Şen, Md
• Email: drelzemsen@gmail.com
• Phone: +905327842151

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.