Can preoperative photon-counting CT help predict heart recovery after bypass surgery?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study will use photon-counting CT scans and echocardiography before surgery, within 7 days after surgery, and around 3 months postoperatively to see if preoperative heart tissue information can predict left ventricular end-systolic volume index after surgery. The study focuses on adults undergoing isolated CABG and will exclude those needing additional major cardiac procedures or with contraindications to contrast-enhanced CT. Primary task is to relate preoperative imaging markers to postoperative cardiac remodeling, adjusting for body size. Blood tests and imaging will be used to characterize patients, with follow-up to ensure data completeness. No interventional treatment is described; the goal is observational insight for future risk stratification.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years and scheduled for isolated CABG.
2. Able to undergo the protocol-specified PCCT examinations after assessment by the clinical and imaging teams.
3. Able to understand the study and provide written informed consent, and willing to attend the 3-month postoperative follow-up.

Exclusion Criteria:

1. Planned concomitant major cardiac surgery, such as valve or aortic surgery, that places the patient outside the target population of isolated CABG.
2. A clinically assessed contraindication to contrast-enhanced CT, including a severe iodinated contrast allergy that cannot be adequately managed, pregnancy, or another examination contraindication.
3. Clinical condition precluding research examinations, or a research workflow that could delay necessary treatment.
4. Unable to complete the informed consent process or explicitly unwilling to attend the required follow-up.

Where it's running

• Department of Radiology, the First Medical Center of Chinese PLA General Hospital/ Chinese PLA Medical School, Beijing, China
  Beijing, China Recruiting

Study contacts

• Study coordinator: Xiaomeng Fan
• Email: fanxiaomeng@301hospital.com.cn
• Phone: 18515817177

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.