Pulpal inflammation and full pulpotomy outcomes in deeply carious mandibular molars
Official title: "The Relationship Between Pulpal Inflammatory Marker Levels in Moderate and Severe Pulpitis and Outcome of Full Pulpotomy in Mandibular Molars With Extremely Deep Caries: A Prospective Cohort Study."
Run by Postgraduate Institute of Dental Sciences Rohtak · NCT07825415 · Data updated 2026-11-12
This study tests whether levels of inflammatory markers IL-1β and IL-6 in deeply decayed mandibular molars predict the success of a full pulpotomy in adults with moderate to severe pulpitis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 86 (estimated) |
| Sponsor | Postgraduate Institute of Dental Sciences Rohtak Academic / other |
| Locations | 1 site (Rohtak, Haryana) |
| Status | Recruiting |
| Started | April 29, 2026 |
| Main results expected | April 28, 2027 |
| Study ends | April 28, 2028 |
| Registry record updated | September 17, 2026 |
| Trial ID | NCT07825415 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18-40 with extremely deep caries in permanent mandibular molars, diagnosed as moderate or severe pulpitis, and ASA 1.
✕Probably not a fit
Patients not showing a relationship between inflammatory markers and outcomes or with different confounding factors may not experience a predictive benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective cohort study investigates how pulpal inflammatory markers IL-1β and IL-6 relate to the outcome of full pulpotomy in mandibular molars with extremely deep caries. Participants are adults aged 18-40 with medically healthy status (ASA 1) and specific radiographic and clinical criteria indicating moderate to severe pulpitis. The intervention is full pulpotomy, and outcomes will be correlated with biomarker levels to see if inflammatory status helps predict treatment success. The study aims to clarify the biological underpinnings of pulpitis severity and improve decision-making for pulpotomy in deeply carious teeth.
Why it matters
Potential benefit: If successful, biomarker testing could help predict pulpotomy outcomes and guide treatment decisions for deeply carious teeth.
How similar studies have gone: Prior research has linked pulpal inflammation markers to local tissue responses, but this specific biomarker-outcome relationship in full pulpotomy is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * o Medically healthy patients (ASA 1). * Age 18-40 years * Patients with extremely deep caries in permanent mandibular molars. * Extremely deep caries, that is penetrating the entire thickness of the dentine without a radiopaque zone separating the lesion from the pulp * PAI score less then or equal to 2 * Pulpal diagnosis via clinical and radiographic examination as well as thermal, electric pulp testing, categorized as moderate pulpitis (Heightened and prolonged reaction to cold, which can last for minutes Possible percussion sensitive Stimulated or spontaneous lingering pain that can be suppressed with analgesics. No sleep disturbance) or severe pulpitis (Severe spontaneous pain Clear lingering pain reaction to cold and warms stimuli Sleeping disturbance and lingering pain Possible sensitive to percussion Extremely deep caries mostly). Exclusion Criteria: * • Primary teeth * Traumatic or mechanical exposure * No pulp exposure after caries excavation. * Haemostasias not achieved within 10 minutes. * Presence of periapical lesion or evidence of internal or external resorption, calcified canals, as assessed by radiographic examination. * Patients with periodontal disease, swelling and sinus tract. * Immunocompromised or pregnant patients, patients with any systemic disease, and a positive history of antibiotic and analgesic use within week before the treatment.
Where it's running
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PGIDS, Rohtak
Rohtak, Haryana, India Recruiting
Study contacts
- Principal investigator: Dr. Akankshya Pattnaik — Postgraduate Institute of Dental sciences, Rohtak 124001
- Study coordinator: Dr. Akankshya Pattnaik, PG student
- Email: akankshyapattnaik44@gmail.com
- Phone: 8658292111
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Partial pulpotomy in mature lower molars with SIP using calcium hypochlorite vs sodium hypochlorite
This trial tests whether washing the exposed pulp with calcium hypochlorite or with sodium hypochlorite during partial pulpotomy in adults helps healing and reduces pain.
-
Direct pulp capping for deep and extremely deep caries in mature molars with reversible pulpitis
This study tests whether direct pulp capping works similarly for deep versus extremely deep caries in adult, mature mandibular molars with reversible pulpitis.
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Direct pulp capping in lower molars with side (proximal) versus top (occlusal) cavities: does the cavity location matter?
This research will test whether direct pulp capping works as well for lower molars with side (proximal) cavities as for those with top (occlusal) cavities in people aged 15–40 who have reversible pulpitis.
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Pulpotomy versus root canal treatment for extremely deep caries
This study tests whether full pulpotomy works as well as root canal treatment for people aged 12 and older with extremely deep caries treated in a university dental clinic.
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Partial pulpotomy outcomes for mature molars with moderate versus severe pulpitis
We will try partial pulpotomy in people aged 15–40 who have mature permanent molars with moderate or severe pulpitis to see if the results differ.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.