Partial pulpotomy outcomes for mature molars with moderate versus severe pulpitis

Outcome of Partial Pulpotomy in Moderate and Severe Pulpitis

We will try partial pulpotomy in people aged 15–40 who have mature permanent molars with moderate or severe pulpitis to see if the results differ.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 120 (estimated)
• Ages: 15 Years to 40 Years
• Sex: All
• Sponsor: Postgraduate Institute of Dental Sciences Rohtak (Academic / other)
• Locations: 1 site (Rohtak, Haryana)
• Trial ID: NCT07123025 on ClinicalTrials.gov

What this trial studies

This interventional trial enrolls patients aged 15–40 with mature permanent mandibular molars and extremely deep caries who respond to pulp sensibility testing and whose bleeding can be controlled within 10 minutes. Participants receive a partial pulpotomy and are classified into moderate or severe pulpitis groups, with clinical and radiographic success checked at 6 and 12 months. Secondary outcomes include oral health–related quality of life and daily postoperative pain recorded for one week. All treatments and follow-up visits are conducted at the Postgraduate Institute of Dental Sciences, Rohtak.

Who should consider this trial

Good fit: People aged 15–40 with mature permanent mandibular molars that have extremely deep caries, a positive vitality test, controllable pulpal bleeding within 10 minutes, normal periapical status (PAI ≤ 2), and healthy periodontal status.

Not a fit: Patients with non-restorable teeth, negative vitality tests, a sinus tract or periapical disease (PAI > 2), or uncontrolled pulpal bleeding are unlikely to benefit.

Why it matters

Potential benefit: If successful, the procedure could let more symptomatic teeth keep healthy pulp and avoid root canal treatment.

How similar studies have performed: Previous small studies have shown partial pulpotomy can succeed for irreversible pulpitis-like conditions, but direct comparisons between moderate and severe cases are limited and inconclusive.

Eligibility criteria

Inclusion Criteria:

1. Patients aged 15-40 years.
2. Mature permanent mandibular molars with extremely deep caries on radiograph, giving positive response to pulp sensibility test.
3. For Moderate Pulpitis- strong, heightened and prolonged reaction to cold, which can last for minutes, possibly percussion sensitive and spontaneous dull pain that can be more or less suppressed with pain medication.

   For Severe Pulpitis- Severe spontaneous pain and clear pain reaction to warmth and cold stimuli, often, sharp to dull throbbing pain, patients have trouble sleeping because of the pain (gets worse when lying down). Tooth is very sensitive to touch and percussion.
4. Pulpal bleeding can be controlled within 10 minutes
5. Patients having normal periapical status with periapical index (PAI) score ≤ 2
6. Periodontally healthy teeth
7. Positive response to pulp sensibility test

Exclusion Criteria:

1. Non restorable teeth
2. Negative response to vitality testing
3. Presence of sinus tract or soft tissue swelling
4. Absence of deep carious lesions radiographically
5. Radiographic signs of internal or external root resorption
6. Patient had moderate to severe pain, but preferred root canal treatment
7. Presence of sound dentin over pulp and pulp not exposed intraoperatively
8. Pulp haemorrhage could not be arrested within 10 minutes.
9. Necrotic pulp evident upon exposure
10. Pregnant women
11. Absence of antagonist teeth

Where this trial is running

Rohtak, Haryana

• PGIDS Rohtak — Rohtak, Haryana, India (Recruiting)

Study contacts

• Principal investigator: Dr. Pankaj Sangwan, MDS — PGIDS, Rohtak, Haryana 124001
• Study coordinator: Dr. Pankaj Sangwan, MDS

Conditions Moderate Pulpitis; Severe Pulpitis; Extremely Deep Caries; partial pulpotomy