Direct pulp capping for deep and extremely deep caries in mature molars with reversible pulpitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–40 with reversible pulpitis and deep or extremely deep caries in mature mandibular molars are assigned to direct pulp capping for either deep or extremely deep lesions. The trial will compare clinical and radiographic success at 7 days, 6 months, and 12 months, and will assess postoperative pain for one week post-procedure. The primary goal is to determine if direct pulp capping yields comparable success in both lesion depths, while the secondary goal is to quantify pain differences after treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. The patient should be 18-40 years of age.
2. Patients with deep and extremely deep caries in permanent mandibular molars.
3. Deep caries lesion -Reaching the inner quarter of dentine on radiograph
4. Extremely deep caries lesion - Caries penetrating the entire thickness of dentin on radiograph.
5. Reversible pulpitis will be diagnosed clinically based on discomfort experienced by the participant when a stimulus such as cold or sweet is applied and goes away within a couple of seconds following removal of stimulus, with no significant radiographic changes in the periapical region of the suspect tooth and pain experienced is not spontaneous.
6. Tooth should give positive response to pulp sensibility testing.
7. Bleeding can be controlled with in 8 minutes.
8. Radiographic finding of periapical index (PAI) score ≤2.
9. Healthy periodontium (probing pocket depth ≤3 mm and mobility within normal limit).

Exclusion criteria

1. Teeth with immature roots.
2. Internal/external resorption.
3. Patient experience spontaneous pain.
4. Negative response to vitality testing
5. No pulp exposure after complete caries excavation.
6. Signs of pulpal necrosis, insufficient bleeding after pulp exposure, sinus tract, swelling.
7. Bleeding could not be controlled in 8 minutes.
8. Pregnant women
9. Contributory medical history (alcoholism, smokers, diabetic, hypertension, drug dependency, Heart or valve disease, hepatitis, herpes, immunodeficiency diseases , infectious diseases, kidney or liver, migraine)

Where it's running

• PGIDS , Rohtak
  Rohtak, Haryana, India Recruiting

Study contacts

• Principal investigator: Dr. Vinay Kumar, MDS — PGIDS, Rohtak
• Study coordinator: Dr. Vinay Kumar, MDS
• Email: 29vinaykr@gmail.com
• Phone: 8901149107

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Direct pulp capping in lower molars with side (proximal) versus top (occlusal) cavities: does the cavity location matter?

  This research will test whether direct pulp capping works as well for lower molars with side (proximal) cavities as for those with top (occlusal) cavities in people aged 15–40 who have reversible pulpitis.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07578662

• Pulpal inflammation and full pulpotomy outcomes in deeply carious mandibular molars

  This study tests whether levels of inflammatory markers IL-1β and IL-6 in deeply decayed mandibular molars predict the success of a full pulpotomy in adults with moderate to severe pulpitis.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07825415

• Partial pulpotomy in mature lower molars with SIP using calcium hypochlorite vs sodium hypochlorite

  This trial tests whether washing the exposed pulp with calcium hypochlorite or with sodium hypochlorite during partial pulpotomy in adults helps healing and reduces pain.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07748676

• Using pulpal blood biomarkers to predict success of vital pulp therapy in symptomatic teeth

  This trial will test whether measuring metabolic biomarkers in pulpal blood at the time of carious pulp exposure can help predict 12-month success of vital pulp treatment in people aged 16–50 with symptomatic deep caries.

  Recruiting University of Baghdad · Baghdad · NCT07452614

• Pulpotomy versus root canal treatment for extremely deep caries

  This study tests whether full pulpotomy works as well as root canal treatment for people aged 12 and older with extremely deep caries treated in a university dental clinic.

  Recruiting National University Hospital, Singapore · Singapore · NCT07242742

• Partial pulpotomy outcomes for mature molars with moderate versus severe pulpitis

  We will try partial pulpotomy in people aged 15–40 who have mature permanent molars with moderate or severe pulpitis to see if the results differ.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07123025

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.