Polishing the Descemet membrane before endothelial keratoplasty for Fuchs endothelial corneal dystrophy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study in patients with Fuchs endothelial corneal dystrophy evaluates the effect of Descemet membrane polishing prior to endothelial cell injection. Eligible participants are adults undergoing endothelial keratoplasty who can provide informed consent. The intervention involves polishing the pathological Descemet membrane to remove guttae before cell therapy, with outcomes focused on graft adhesion and cell survival. The study is conducted at multiple centers in France, led by CHU Saint-Etienne, to determine whether this step enhances treatment effectiveness. Safety and feasibility data will be collected to inform future adoption of the approach.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient affiliated with or entitled to a social security scheme
* Patient scheduled for endothelial keratoplasty for Fuchs endothelial corneal dystrophy
* Patient having received full information and having provided written informed consent

Exclusion Criteria:

* Pregnant women
* Adults under legal protection (guardianship/curatorship) or unable to provide informed consent

Where it's running

• CHU de Saint-Etienne
  Saint-Etienne, France, France Recruiting
• Hopital de Mercy
  Metz, Metz, France Not yet recruiting
• Cochin Hospital
  Paris, Paris, France Not yet recruiting
• Hôpital Fondation Rothschild
  Paris, Paris, France Not yet recruiting
• Centre Hospitalier Universitaire de Rouen
  Rouen, Rouen, France Not yet recruiting

Study contacts

• Principal investigator: Gilles THURET, MD-PhD — Centre Hospitalo-Universitaire de Saint-Etienne
• Study coordinator: Gilles THURET, MD PhD
• Email: gilles.thuret@univ-st-etienne.fr
• Phone: (0)4 77 12 77 96

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Lying on your back after DMEK: 1 day versus 5 days

  This trial sees if lying on your back for five days after DMEK surgery helps the transplant stick better than lying on your back for one day for people with Fuchs endothelial corneal dystrophy or corneal failure.

  Recruiting University Hospital Heidelberg · Heidelberg · NCT07373821

• VALIDATING the SUCCESS Score to predict need for endothelial keratoplasty after cataract surgery in Fuchs dystrophy

  This study will test whether the SUCCESS Score, with corneal densitometry, can predict which people with Fuchs endothelial corneal dystrophy having cataract surgery will later need endothelial keratoplasty.

  Recruiting Instituto Ramón y Cajal de Investigación Sanitaria · Madrid, Madrid · NCT07265388

• DT-168 for people with Fuchs endothelial corneal dystrophy who are having a corneal transplant

  This study will test whether DT-168 eye drops are safe, well tolerated, and how they act in people with Fuchs endothelial corneal dystrophy who are scheduled for corneal transplant.

  Recruiting at 2 sites Phase 2 Design Therapeutics, Inc. · Indianapolis, Indiana and 1 other locations · NCT07024693

• Comparing femtosecond laser-assisted versus conventional cataract surgery for people with Fuchs endothelial corneal dystrophy

  This study will test whether femtosecond laser-assisted cataract surgery or conventional phacoemulsification better preserves corneal endothelial cells and vision in adults with moderate to severe Fuchs endothelial corneal dystrophy who need cataract surgery.

  Recruiting Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT06966167

• Observing outcomes of posterior lamellar keratoplasty for eye conditions

  This study looks at how well two types of eye surgeries for conditions like Fuchs' dystrophy and bullous keratopathy work in helping patients see better over time.

  Recruiting Centre Hospitalier Régional Metz-Thionville · Metz · NCT06859411

• Using N-acetyl cysteine eye drops to treat Fuchs Endothelial Corneal Dystrophy

  This study is testing if N-acetyl cysteine eye drops can help people with Fuchs Endothelial Corneal Dystrophy and cataracts feel better and improve their eye health before surgery.

  Recruiting Phase 2 Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT04440280

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.