Observing outcomes of posterior lamellar keratoplasty for eye conditions
Official title: Prognosis of Posterior Lamellar Keratoplasty: an Observational Cohort Study
Run by Centre Hospitalier Régional Metz-Thionville · NCT06859411 · Data updated 2026-11-12
This study looks at how well two types of eye surgeries for conditions like Fuchs' dystrophy and bullous keratopathy work in helping patients see better over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Centre Hospitalier Régional Metz-Thionville Academic / other |
| Locations | 1 site (Metz) |
| Status | Recruiting |
| Started | June 1, 2024 |
| Main results expected | January 1, 2040 |
| Study ends | January 1, 2040 |
| Registry record updated | June 24, 2026 |
| Trial ID | NCT06859411 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients who have received posterior lamellar keratoplasty at the Metz-Thionville Regional Hospital between 2012 and 2030.
✕Probably not a fit
Patients who refuse to participate in the study will not benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients who have undergone posterior lamellar keratoplasty techniques, specifically DSAEK and DMEK, to treat Fuchs' endothelial corneal dystrophy and pseudophakic bullous keratopathy. The study aims to evaluate the prognosis and visual acuity outcomes of these surgical interventions over a specified period. By analyzing data from patients treated at the Metz-Thionville Regional Hospital, researchers will gather insights into the effectiveness and long-term results of these advanced corneal surgeries.
Why it matters
Potential benefit: If successful, this study could provide valuable information on the effectiveness of posterior lamellar keratoplasty techniques, leading to improved patient outcomes in corneal surgeries.
How similar studies have gone: Other studies have shown promising results with similar posterior lamellar keratoplasty techniques, indicating a potential for success in this observational study.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients who received a posterior lamellar keratoplasty in Metz-Thionville Regional Hospital between 2012 and 2030 Exclusion Criteria: * patients refusing to take part in the study
Where it's running
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CHR Metz-Thionville Hopital de Mercy
Metz, France Recruiting
Study contacts
- Principal investigator: Jean-Marc PERONE, MD — CHR Metz Thionville Hopital de Mercy
- Study coordinator: Arpiné EL NAR, PhD
- Email: projet-recherche-clinique@chr-metz-thionville.fr
- Phone: 0033387557766
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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EO2002 therapy for corneal edema due to endothelial dysfunction
This trial tests whether a single intracameral injection of EO2002 cells can improve vision and reduce corneal thickness in adults with corneal edema from endothelial dysfunction.
-
Polishing the Descemet membrane before endothelial keratoplasty for Fuchs endothelial corneal dystrophy
This trial tests whether polishing the diseased Descemet membrane before injecting cultured endothelial cells helps improve graft adhesion and outcomes for people with Fuchs endothelial corneal dystrophy.
-
Lying on your back after DMEK: 1 day versus 5 days
This trial sees if lying on your back for five days after DMEK surgery helps the transplant stick better than lying on your back for one day for people with Fuchs endothelial corneal dystrophy or corneal failure.
-
PVEK corneal implant to treat corneal swelling
This study will test a PVEK tissue‑engineered corneal implant to see if it is safe and helps people with corneal swelling from Fuchs' endothelial dystrophy or pseudophakic bullous keratopathy who need endothelial keratoplasty.
-
VALIDATING the SUCCESS Score to predict need for endothelial keratoplasty after cataract surgery in Fuchs dystrophy
This study will test whether the SUCCESS Score, with corneal densitometry, can predict which people with Fuchs endothelial corneal dystrophy having cataract surgery will later need endothelial keratoplasty.
-
DT-168 for people with Fuchs endothelial corneal dystrophy who are having a corneal transplant
This study will test whether DT-168 eye drops are safe, well tolerated, and how they act in people with Fuchs endothelial corneal dystrophy who are scheduled for corneal transplant.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.