Lying on your back after DMEK: 1 day versus 5 days

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial assigns patients who receive Descemet membrane endothelial keratoplasty (DMEK) to lie supine for either 1 day or 5 days after surgery to compare graft attachment and the need for additional procedures. Participants wear a movement sensor that records head position to measure adherence and undergo regular vision tests and anterior-segment OCT imaging to quantify any detachment. Patients also complete symptom questionnaires, keep a diary of comfort and issues, and report any adverse events such as back pain. Primary outcomes include detachment size and rebubbling rates, with safety and tolerability as secondary outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Fuchs Endothelial Corneal Dystrophy Bullous Keratopathy

Exclusion Criteria:

Comorbidities preventing supine positioning

Where it's running

• Department of Ophthalmology, University Hospital Heidelberg
  Heidelberg, Germany Recruiting

Study contacts

• Study coordinator: Maximilian Friedrich, MD
• Email: maximilian.friedrich@med.uni-heidelberg.de
• Phone: +49 6221 56 37749

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Polishing the Descemet membrane before endothelial keratoplasty for Fuchs endothelial corneal dystrophy

  This trial tests whether polishing the diseased Descemet membrane before injecting cultured endothelial cells helps improve graft adhesion and outcomes for people with Fuchs endothelial corneal dystrophy.

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• VALIDATING the SUCCESS Score to predict need for endothelial keratoplasty after cataract surgery in Fuchs dystrophy

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• DT-168 for people with Fuchs endothelial corneal dystrophy who are having a corneal transplant

  This study will test whether DT-168 eye drops are safe, well tolerated, and how they act in people with Fuchs endothelial corneal dystrophy who are scheduled for corneal transplant.

  Recruiting at 2 sites Phase 2 Design Therapeutics, Inc. · Indianapolis, Indiana and 1 other locations · NCT07024693

• Comparing femtosecond laser-assisted versus conventional cataract surgery for people with Fuchs endothelial corneal dystrophy

  This study will test whether femtosecond laser-assisted cataract surgery or conventional phacoemulsification better preserves corneal endothelial cells and vision in adults with moderate to severe Fuchs endothelial corneal dystrophy who need cataract surgery.

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• Observing outcomes of posterior lamellar keratoplasty for eye conditions

  This study looks at how well two types of eye surgeries for conditions like Fuchs' dystrophy and bullous keratopathy work in helping patients see better over time.

  Recruiting Centre Hospitalier Régional Metz-Thionville · Metz · NCT06859411

• Using N-acetyl cysteine eye drops to treat Fuchs Endothelial Corneal Dystrophy

  This study is testing if N-acetyl cysteine eye drops can help people with Fuchs Endothelial Corneal Dystrophy and cataracts feel better and improve their eye health before surgery.

  Recruiting Phase 2 Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT04440280

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.