Precise endoscopic nitroglycerin to prevent pancreatitis after ERCP

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults undergoing ERCP with sphincterotomy for common bile duct stone removal will receive a targeted endoscopic application of nitroglycerin or a normal saline control during the procedure, and outcomes will track rates of post-ERCP pancreatitis and related complications. The protocol is interventional (Phase 4) and enrolls patients aged 18 and older who consent to ERCP and sphincterotomy, excluding those with pancreatic cancer, shock, nitroglycerin allergy, angle-closure glaucoma, severe anemia, or current PDE5 inhibitor use. Procedural exposure is brief and delivered at the time of ERCP, with follow-up to capture clinical pancreatitis, severity, and any adverse events. The trial is conducted at National Cheng Kung University Hospital in Tainan, Taiwan.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Eligible participants include patients aged ≥ 18 years who accept ERCP and sphincterotomy for common bile duct (CBD) stone extraction.

Exclusion Criteria:

* patients with pancreatic cancer
* shock status (systolic blood pressure \< 90 mmHg or using inotropic agents)
* allergy to NTG
* angle-closure glaucoma
* severe anemia
* patients on PDE 5 inhibitors

Where it's running

• National Cheng Kung University Hospital
  Tainan, Other (Non U.s.), Taiwan Recruiting

Study contacts

• Study coordinator: Hsueh-Chien Chiang, MD
• Email: scion456scion@gmail.com
• Phone: +88662353535

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.