Pharmacokinetics of Whole-Grain Corn: What Happens After Eating
Official title: Pharmacokinetic (PK) Study of Phytochemicals in Whole Grains (WGs)- Corn
Run by North Carolina Agriculture & Technical State University · NCT07767162 · Data updated 2026-11-12
This study tests how healthy adults absorb and excrete components from whole-grain corn by giving two types of corn on different days and measuring biomarkers in blood, urine, and feces.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years to 70 Years |
| Sex | All |
| Enrollment | 16 (estimated) |
| Sponsor | North Carolina Agriculture & Technical State University Academic / other |
| Locations | 1 site (Kannapolis, North Carolina) |
| Status | Recruiting |
| Started | August 4, 2026 |
| Main results expected | November 25, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | August 24, 2026 |
| Trial ID | NCT07767162 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 25-70 with BMI 18-30, no food allergies to test foods, English literacy, and willingness to follow dietary restrictions.
✕Probably not a fit
Individuals with active comorbidities, smokers, or those unable to comply with dietary restrictions may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pharmacokinetic study in healthy adults compares whole-grain corn to refined corn in a randomized crossover design. Participants consume two servings of either grain, with samples collected over 48 hours to map absorption and excretion. Researchers use targeted and untargeted metabolomics to identify biomarkers of corn intake and to build a whole-grain metabolite database. The study includes a 6-day washout between visits to ensure no carryover effects. The goal is to identify corn phytochemicals and metabolites that can serve as objective measures of whole-grain corn intake in Americans.
Why it matters
Potential benefit: Identifying objective biomarkers could improve dietary assessment and understanding of whole-grain corn exposure.
How similar studies have gone: Previous pharmacokinetic and metabolomics studies have successfully identified dietary biomarkers, supporting feasibility for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 25-70 years * Body mass index (BMI) between 18 and 30 kg/m² * Able to read, speak, and understand English * No known allergy or intolerance to the test foods * Normal blood and urine biochemical parameters * No antibiotic use within the past 6 months * Willing and able to comply with all study procedures, including dietary restrictions throughout the study period * No medical conditions or lifestyle factors that, in the opinion of the investigators, would interfere with the study objectives Exclusion Criteria: * Active disease, including gout, heart disease, peripheral vascular disease, kidney disease, liver disease, cancer, diabetes, gastrointestinal disorders, or endocrine disorders that may interfere with the study * Current smoker or use of tobacco products * Unwilling or unable to comply with the required dietary restrictions during the study period
Where it's running
-
Clinical Research Core (CRC)
Kannapolis, North Carolina, United States Recruiting
Study contacts
- Study coordinator: Shengmin Sang
- Email: ssang@ncat.edu
- Phone: 704-250-5710
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.