Inhaling hydrogen before exercise to see how the body uses energy in healthy women
Official title: Effect of Repeated Pre-exercise Inhalation of Molecular Hydrogen on Metabolic Response During Graded Exercise in Healthy Women: A Randomized, Double-blind, Placebo-controlled Crossover Trial
Run by Palacky University · NCT07644000 · Data updated 2026-11-12
This study tests whether inhaling molecular hydrogen for a week changes metabolic responses during graded exercise in healthy young women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 30 Years |
| Sex | Women only |
| Enrollment | 22 (estimated) |
| Sponsor | Palacky University Academic / other |
| Locations | 1 site (Olomouc) |
| Status | Recruiting |
| Started | June 22, 2026 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | June 25, 2026 |
| Trial ID | NCT07644000 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adult females aged 18-30 with regular menstrual cycles and no contraindications to exercise testing.
✕Probably not a fit
Individuals with pregnancy, cardiovascular or respiratory disease, or those using medications or supplements affecting metabolism may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized crossover study in healthy adult females to compare the metabolic effects of inhaling molecular hydrogen versus placebo. Each participant experiences both interventions in random order, separated by a two-week washout. Participants inhale hydrogen or placebo for 60 minutes daily for seven days, with a graded exercise test on the seventh day of each intervention to measure metabolic and cardiorespiratory responses. Outcomes include resting and during-exercise variables such as respiratory exchange ratio, oxygen uptake, capillary biomarkers, and perceived exertion. The study uses a controlled gas delivery system and standard exercise testing to assess whether hydrogen inhalation alters metabolic response during exercise.
Why it matters
Potential benefit: If successful, inhaled hydrogen could potentially modulate metabolic responses during exercise in healthy individuals.
How similar studies have gone: Existing studies in metabolic modulation during exercise with hydrogen are limited; this trial explores a novel crossover approach in humans.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy female participants. * Regular menstrual cycle with exercise testing scheduled outside the menstrual phase. * Signed informed consent. Exclusion Criteria: * Pregnancy or breastfeeding. * History or presence of cardiovascular disease. * History or presence of respiratory disease. * Regular use of medications affecting metabolism. * Use of dietary supplements affecting metabolism within 14 days prior to intervention. * Strenuous physical activity within 24 hours prior to exercise testing. * Any contraindication to exercise testing or study participation determined by a physician.
Where it's running
-
Palacky University, Faculty of Physical Culture
Olomouc, Czechia Recruiting
Study contacts
- Principal investigator: Tereza Rysava — Palacky University
- Study coordinator: Tereza Rysava
- Email: tereza.rysava01@upol.cz
- Phone: +420585636154
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.