Olive oil extract for improving knee comfort and function
Official title: A 6-Week, Randomized, Double-Blind, Placebo-Controlled Virtual Study Evaluating an Olive Oil Extract on Knee Comfort and Function
Run by Applied Food Sciences Inc. · NCT07514013 · Data updated 2026-11-12
This will test whether taking an olive oil extract every day for six weeks helps reduce knee pain and improve knee function in adults 40–75 who have ongoing knee discomfort.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 75 Years |
| Sex | All |
| Enrollment | 168 (estimated) |
| Sponsor | Applied Food Sciences Inc. Industry-sponsored |
| Locations | 1 site (San Francisco, California) |
| Status | Recruiting |
| Started | April 2026 |
| Main results expected | October 1, 2026 |
| Study ends | November 1, 2026 |
| Registry record updated | April 15, 2026 |
| Trial ID | NCT07514013 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are English-speaking adults aged 40–75 with self-reported knee discomfort for at least three months who can take a daily capsule, complete digital questionnaires and at-home functional tests, and use a compatible activity tracker.
✕Probably not a fit
People with diagnosed inflammatory joint diseases, a prior diagnosis of knee disease, recent or significant knee surgery, or other systemic conditions affecting the knee are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind, placebo-controlled study gives adults with at least three months of knee discomfort one capsule daily of either an olive oil extract or a matched placebo for six weeks. Participants complete baseline and follow-up digital questionnaires about knee pain, stiffness, and function, perform two self-administered functional movement tests (Stair Climb Test and Timed Up and Go), and record any pain medication use or side effects. Optional wearable data on sleep and activity and home-collected saliva samples will provide supportive real-world and exploratory measures. The trial is conducted through the Alethios platform with remote consent and at-home procedures to minimize participant burden.
Why it matters
Potential benefit: If successful, daily olive oil extract could reduce knee discomfort and improve day-to-day knee function for adults with chronic knee pain.
How similar studies have gone: Some small clinical and preclinical studies of olive oil polyphenols and related extracts suggest potential benefits for joint comfort and inflammation, but large, definitive trials are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Participants must meet all of the following criteria to be eligible for participation: * Adults aged 40 to 75 years * Self-reported knee discomfort for at least 3 months * Willing and able to take one study capsule daily for the duration of the study * Willing and able to complete digital questionnaires, functional movement tasks, and other study activities using the Alethios platform * Willing and able to wear a compatible activity-tracking device throughout the study * Willing and able to collect saliva samples at home using a provided kit, if applicable * Able to read and understand English * Willing to provide informed consent electronically Exclusion Criteria: Participants will be excluded if any of the following apply: * Diagnosis of inflammatory joint disease (e.g., rheumatoid arthritis) or other systemic inflammatory conditions affecting the knee * Any current or prior diagnosis from a licensed medical provider of knee disease * Knee surgery or significant knee injury within the past 6 months * Planned knee surgery during the study period * Known allergy or sensitivity to olive-derived products or any component of the study product * Current use of investigational drugs or participation in another research study during the study period * Any medical condition or circumstance that, in the opinion of the investigator, would make participation unsafe or interfere with study participation or data quality
Where it's running
-
Alethios, Inc.
San Francisco, California, United States Recruiting
Study contacts
- Principal investigator: Chad Kerksick, PhD
- Study coordinator: Christine Fields, PhD
- Email: cfields@appliedfoods.com
- Phone: 8475508978
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.