Biomarker test for brown rice components in healthy adults
Official title: Pharmacokinetic (PK) Study of Phytochemicals in Whole Grains (WGs)- Brown Rice
Run by North Carolina Agriculture & Technical State University · NCT07898137 · Data updated 2026-11-12
This study will test whether specific biomarkers in blood and urine reflect acute brown rice intake in healthy men and women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years to 70 Years |
| Sex | All |
| Enrollment | 16 (estimated) |
| Sponsor | North Carolina Agriculture & Technical State University Academic / other |
| Locations | 1 site (Kannapolis, North Carolina) |
| Status | Recruiting |
| Started | January 15, 2027 |
| Main results expected | May 15, 2027 |
| Study ends | June 30, 2027 |
| Registry record updated | October 27, 2026 |
| Trial ID | NCT07898137 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 25-70 without chronic diseases or recent antibiotic use, willing to follow dietary restrictions.
✕Probably not a fit
Individuals with certain medical conditions or dietary restrictions that conflict with the study protocol may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized crossover study in healthy adults examines pharmacokinetic markers after consuming two servings of either whole-grain brown rice or refined white rice. Blood and urine samples are collected over 48 hours after each feeding to identify exposure biomarkers and understand the body's handling of brown rice phytochemicals. Researchers will use targeted metabolomics to develop methods and an in-house metabolite database, followed by untargeted metabolomics to explore postprandial biomarker responses. The goal is to determine objective biomarkers that indicate total and specific whole grains consumed by Americans.
Why it matters
Potential benefit: If successful, participants and clinicians may gain objective tools to monitor whole-grain intake through biological biomarkers.
How similar studies have gone: Previous metabolomics studies have identified dietary biomarkers; this study applies similar approaches to brown rice in a crossover design.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 25-70 years * Body mass index (BMI) between 18 and 30 kg/m² * Able to read, speak, and understand English * No known allergy or intolerance to the test foods * Normal blood and urine biochemical parameters * No antibiotic use within the past 6 months * Willing and able to comply with all study procedures, including dietary restrictions throughout the study period * No medical conditions or lifestyle factors that, in the opinion of the investigators, would interfere with the study objectives Exclusion Criteria: * Active disease, including gout, heart disease, peripheral vascular disease, kidney disease, liver disease, cancer, diabetes, gastrointestinal disorders, or endocrine disorders that may interfere with the study * Current smoker or use of tobacco products * Unwilling or unable to comply with the required dietary restrictions during the study period
Where it's running
-
Clinical Research Core (CRC)
Kannapolis, North Carolina, United States Recruiting
Study contacts
- Study coordinator: Shengmin Sang
- Email: ssang@ncat.edu
- Phone: 704-250-5710
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.