Biphasic IVM for POSEIDON Group 1 in young women with poor response
Official title: Efficacy and Safety of Biphasic IVM in Low Prognosis Patients Classified as Poseidon Group 1A
Run by Mỹ Đức Hospital · NCT07632300 · Data updated 2026-11-12
This trial tests whether a two-step in vitro maturation process can help young women with normal ovarian reserve who retrieve too few eggs after standard stimulation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 35 Years |
| Sex | Women only |
| Enrollment | 25 (estimated) |
| Sponsor | Mỹ Đức Hospital Academic / other |
| Locations | 1 site (Ho Chi Minh City, Hồ Chí Minh) |
| Status | Recruiting |
| Started | June 12, 2026 |
| Main results expected | December 30, 2026 |
| Study ends | March 30, 2027 |
| Registry record updated | June 17, 2026 |
| Trial ID | NCT07632300 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18 to under 35 who previously had poor response (POSEIDON Group Ia) to standard stimulation and are willing to use biphasic-IVM and freeze-all embryos.
✕Probably not a fit
Patients with non-responder ovarian biology or contraindications to IVM may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study explores biphasic in vitro maturation (IVM) to improve egg yield in women under 35 with POSEIDON Group 1a characteristics who previously had poor response to ovarian stimulation. Immature eggs are collected with minimal hormone stimulation and matured in the lab using a two-phase process. The primary aim is to see how many mature oocytes can be obtained and whether this approach can reduce costs and OHSS risk compared with conventional stimulation. Participants will freeze all embryos and undergo subsequent transfers after embryo development is assessed. The study is conducted at My Duc Hospital/IVFMD in Ho Chi Minh City and does not list a sponsor-for-profit affiliation beyond the lead hospital.
Why it matters
Potential benefit: If successful, biphasic-IVM could increase the number of usable eggs and embryos for young women with poor ovarian response, potentially reducing treatment burden and costs.
How similar studies have gone: Prior studies in IVM have shown mixed results; the biphasic approach for this specific POSEIDON subgroup is exploratory and not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged 18 - \< 35 years * At least one IVF cycle have been failed and classified as having a poor response to POSEIDON group Ia. * POSEIDON group Ia ( \< 35 age; AMH \>= 1.2 ng/ml and/or AFC \>=5 antral follicles; have \< 4 oocytes was retrieved at previous IVF cycle) * Agree to apply biphasic-IVM treatment. * Agree to freeze all embryos and to transfer the frozen embryos afterward. * Agree to participate in the study. Exclusion Criteria: * Egg-donation cycle * Uterine abnormalities: adenomyosis, large uterine fibroids (≥5 cm), bicornuate uterus, uterine adhesions. * Sperm surgical (PESA, TESE, mTESE) * PGT
Where it's running
-
IVFMD, My Duc Hospital
Ho Chi Minh City, Hồ Chí Minh, Vietnam Recruiting
Study contacts
- Principal investigator: Ho L. Le, MD
- Study coordinator: Ho L. Le, MD
- Email: bsho.ll@myduchospital.vn
- Phone: +84356177147
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.