Peroxide vs Non-Peroxide In-Office Tooth Bleaching
Official title: Bleaching Efficacy, Color Durability, and Tooth Sensitivity After In-Office Bleaching With Peroxide Versus Non-Peroxide Systems: A Randomized Clinical Trial
Run by Minia University · NCT07818031 · Data updated 2026-11-12
This study tests whether peroxide-based in-office whitening works differently from non-peroxide whitening in adults aged 18–45 with healthy teeth as measured by color change and sensitivity over six months.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Minia University Academic / other |
| Locations | 1 site (Minya, Minya Governorate) |
| Status | Recruiting |
| Started | August 15, 2026 |
| Main results expected | February 15, 2027 |
| Study ends | March 15, 2027 |
| Registry record updated | October 15, 2026 |
| Trial ID | NCT07818031 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–45 with healthy maxillary anterior teeth, good oral health, and baseline shade suitable for bleaching.
✕Probably not a fit
Individuals with active dental issues, intrinsic discoloration, pregnancy, or recent whitening products may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial compares peroxide-based and non-peroxide in-office tooth bleaching systems. Participants are randomly assigned to one of two treatment groups and assessed for initial color, immediate whitening, color durability, and tooth sensitivity over a six‑month follow-up. Standardized methods will be used to measure tooth color and track safety and tolerability. The study aims to inform clinicians about the relative effectiveness and safety of the two bleaching approaches. Outcomes will help guide esthetic dentistry decisions for patients seeking in-office whitening.
Why it matters
Potential benefit: If effective, the study could help patients choose the most reliable and comfortable bleaching option for lasting whitening.
How similar studies have gone: Similar approaches have shown measurable color changes with peroxide systems; non-peroxide options are less widely studied but have potential benefits in sensitivity.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18-45 years. * Good general health. * Presence of all maxillary anterior teeth free from restorations, caries, or structural defects. * Baseline tooth shade suitable for bleaching assessment. * Good oral hygiene and periodontal health. * Willingness to comply with the study protocol and attend all follow-up visits. * Signed informed consent. Exclusion Criteria: * Pregnancy or lactation. * History of tooth hypersensitivity. * Active caries or defective restorations in the anterior teeth. * Intrinsic tooth discoloration (e.g., fluorosis, tetracycline staining). * Ongoing orthodontic treatment. * Smoking. * Use of tooth-whitening products within the previous 6 months. * Allergy to any component of the bleaching materials.
Where it's running
-
Minia University Hospital
Minya, Minya Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Esraa Eid, MSc
- Email: esraa.korny@nub.edu.eg
- Phone: +20 1019243773
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.