Perineural injection therapy for frozen shoulder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center randomized pilot compares weekly perineural injections of 5% dextrose for six weeks plus physiotherapy and oral analgesics (excluding NSAIDs) against conventional therapy (physiotherapy and analgesics including NSAIDs) in adults with adhesive capsulitis. Participants attend follow-up visits at week 6, one month, and three months after treatment while performing daily home exercises and keeping a diary of analgesic use and side effects. The trial measures pain, shoulder range of motion, function, and any adverse events to determine whether adding PIT improves outcomes and is safe. Results will inform whether larger trials are warranted.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18 and above.
2. Diagnosed with primary adhesive capsulitis by a specialist.
3. Limitation of range of motion ≥ 50% relative to the normal side or normal reference (in patient with bilateral adhesive capsulitis) in three or more movement directions (i.e., external rotation, abduction, forward flexion, and internal rotation).
4. Chronic adhesive capsulitis shoulder pain lasting for at least 3 months.
5. Pain score of at least 4/10 on the Numerical Rating Scale (NRS) during movement, indicating at least moderate pain severity.
6. Consented to the study.

Exclusion Criteria:

1. Received any shoulder pain injection within the past 6 weeks or surgical intervention such manipulation under anesthesia, arthroscopic capsular release, or open surgery for capsular release.
2. Diagnosed with other shoulder pathology such as neurologic deficits affecting shoulder function, tumour, rotator cuff injury or fracture.
3. Has history of allergy to dextrose solution.
4. Patients receiving steroidsimmunosuppressants, psychotropic medication, or other medications that may affect, the clinical outcomes
5. Patients with haemorrhagic disease, taking anticoagulant drugs, or patients with severe diabetes mellitus having an increased risk of infection (HBA1c \>8%)
6. Do not understand Malay or English language.
7. Unable to follow a 3 steps command.

Where it's running

• Hospital Al-Sultan Abdullah, UiTM Puncak Alam
  Kuala Selangor, Selangor, Malaysia Recruiting

Study contacts

• Principal investigator: Noor Hafizah Samsudin Bahari, MD(UKM) — Faculty of Medicine, Universiti Teknologi MARA, Sg Buloh Campus
• Study coordinator: Noor Hafizah Samsudin Bahari, MD(UKM)
• Email: 2023204074@student.uitm.edu.my
• Phone: +60333963395

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Additional effects of thoracic mobilization versus manipulation with standard physical therapy in adhesive capsulitis

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• Shoulder Frozen Shoulder: TAME vs Corticosteroid Injection

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• Gong's Mobilization With and Without Niel-Asher Technique for Frozen Shoulder

  This trial tests whether Gong's mobilization alone or with the Niel-Asher trigger-point technique can ease pain, improve shoulder movement, and reduce disability in adults with adhesive capsulitis.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07628335

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.