Peptide cream on forearm skin: does it speed up barrier recovery
Official title: Evaluation of the Efficacy of a Topical Formulation Containing Acetyl Hexapeptide-37 on Skin Barrier Recovery of the Forearm After Controlled Damage Using the Tape-stripping Method
Run by University of Split, School of Medicine · NCT07614698 · Data updated 2026-11-12
A peptide-based cream with Acetyl Hexapeptide-37 is tested on healthy adults to see if it helps the skin recover faster after a mild disruption compared with a placebo.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Split, School of Medicine Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Split) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | January 2027 |
| Study ends | January 2027 |
| Registry record updated | June 17, 2026 |
| Trial ID | NCT07614698 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adult volunteers without skin disease or active skin damage at measurement sites, not pregnant or breastfeeding, and without recent use of corticosteroids, immunomodulators, emollients, or high UV exposure.
✕Probably not a fit
Individuals with skin diseases, damaged measurement sites, or recent use of conflicting medications or products may not experience benefit and could be excluded for safety.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study tests a topical formulation containing Acetyl Hexapeptide-37 on healthy volunteers. Each participant will have one forearm treated with the peptide cream and the other forearm with placebo after a controlled skin barrier disruption using tape-stripping. Non-invasive assessments will measure skin recovery, hydration, and redness over multiple visits. The trial uses a contralateral design to directly compare treated and control sites within the same individual. Safety and tolerability will be monitored according to standard dermatological trial practices.
Why it matters
Potential benefit: If successful, the peptide cream could help speed skin barrier recovery and reduce redness after minor skin barrier disruptions.
How similar studies have gone: Previous work in topical peptides has shown potential for supporting skin barrier properties, but this specific contralateral, peptide-versus-placebo design is relatively novel in healthy volunteers.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy volunteers who gave written informed consent Exclusion Criteria: * skin disease * skin damage on measurement sites * use of corticosteroids, antihistamines and immunomodulators a month prior the inclusion and during the trial * use of emollients three days prior the inclusion in the trial * non-adherence to the trial protocol * exposure to artificial and excessive natural ultraviolet (UV) radiation * pregnancy or breastfeeding * immunosuppression * allergic or irritant reactions to the constituents of the cream
Where it's running
-
University of Split School of Medicine
Split, Croatia Recruiting
Study contacts
- Study coordinator: Josipa Bukić
- Email: jbukic@mefst.hr
- Phone: +385917933753
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.