Investigating markers in relapsing-remitting multiple sclerosis
Investigation of Subclinical Markers of Multiple Sclerosis
University of Split, School of Medicine · NCT04604041
This study is testing different markers in people with relapsing-remitting multiple sclerosis to see how they can help us understand the disease better and improve treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University of Split, School of Medicine (other) |
| Locations | 1 site (Split) |
| Trial ID | NCT04604041 on ClinicalTrials.gov |
What this trial studies
This study aims to explore clinical, neurophysiological, and immunological markers in patients with relapsing-remitting multiple sclerosis (RRMS), including those receiving immunomodulatory treatment. It employs navigated transcranial magnetic stimulation (nTMS) to assess central nervous system function, alongside electromyoneurography (EMNG) for peripheral nervous system evaluation. Participants will undergo a series of neuropsychological assessments and blood tests to analyze immune markers. The findings may enhance understanding of MS pathophysiology and inform better diagnostic and treatment strategies.
Who should consider this trial
Good fit: Ideal candidates are individuals with a documented diagnosis of relapsing-remitting MS and an EDSS score between 0 and 3.5.
Not a fit: Patients with contraindications such as metal implants, recent pregnancies, or head trauma may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment approaches for patients with relapsing-remitting multiple sclerosis.
How similar studies have performed: While similar studies have explored neurophysiological markers in MS, this specific approach combining multiple assessment techniques is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects with a documented diagnosis of relapsing-remitting MS according to the Mc Donald criteria (2005) and with EDSS achievement of 0-3.5 according to the modified Kurtzke's EDSS (Expanded disability status scale) for the assessment of neurological function and incapacity of patients with multiple sclerosis Exclusion Criteria: * Patients with metals in the body (e.g. pacemaker, dentures) * Patients with new pregnancies (verbally confirmed) * Patients with new head trauma * Subjects unwilling to sign a consent or follow study procedures
Where this trial is running
Split
- University of Split School of Medicine — Split, Croatia (RECRUITING)
Study contacts
- Principal investigator: Maja Rogić Vidaković, MSc, PhD — University of Split, School of Medicine
- Study coordinator: Maja Rogić Vidaković, MSc, PhD
- Email: maja.rogic@mefst.hr
- Phone: 0038598508210
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis, multiple sclerosis, relapsing remitting, TMS, Cytometry, ELISA, corticosteroids