Glycyrrhetinic acid cream for irritant contact dermatitis relief

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial tests whether formulations containing glycyrrhetinic acid can lessen skin irritation caused by a controlled irritant. Participants are healthy adults with intact skin and no recent corticosteroid or emollient use, and they will receive low- or high-dose glycyrrhetinic acid, placebo, or no treatment after exposure to a standardized irritant. The study compares responses across different formulations to see if the anti-inflammatory properties of glycyrrhetinic acid improve irritation outcomes. Safety and tolerability are monitored through the dosing period. The results aim to inform whether glycyrrhetinic acid–enriched emollients could be a useful option for irritated skin in the general population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy adult participants aged 18 years or older, of any sex.
* Intact, healthy skin at the test sites.
* No use of systemic or topical corticosteroids, immunomodulators, or antihistamines within the previous three months.
* No use of topical emollients on the test sites within the previous seven days.

Exclusion Criteria:

* Pregnant women, women suspected of being pregnant, and breastfeeding women.
* Non-compliance with the study protocol.
* Voluntary withdrawal or personal decision not to continue participation.

Where it's running

• University of Split School of Medicine
  Split, Croatia Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.