Helichrysum italicum extract cream for skin barrier recovery in irritant contact dermatitis
Official title: Assessment of the Effect of Helichrysum Italicum Extract in Irritant Contact Dermatitis: A Randomized Controlled Clinical Trial
Run by University of Split, School of Medicine · NCT07676253 · Data updated 2026-11-12
A topical cream with Helichrysum italicum extract is tested to see if it helps healthy adults recover their skin barrier after irritation better than a standard moisturizer or no treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Split, School of Medicine Academic / other |
| Locations | 1 site (Split) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | January 2027 |
| Study ends | January 2027 |
| Registry record updated | July 17, 2026 |
| Trial ID | NCT07676253 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adult volunteers without skin disease, not pregnant or breastfeeding, and with no allergy to cream components.
✕Probably not a fit
Individuals with skin diseases, ongoing skin damage at measurement sites, recent use of corticosteroids or immunomodulators, or known allergies to cream ingredients may not receive benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares a cream containing Helichrysum italicum extract with a placebo cream and with no treatment to see if it speeds skin barrier recovery after experimentally induced irritant contact dermatitis. Outcomes include measures of transepidermal water loss, skin redness, and hydration to determine any added benefit from the extract. The trial also monitors safety and tolerability of the Helichrysum-containing formulation in healthy volunteers. Participants are healthy adults who consent to participate and do not have skin diseases or recent use of immunomodulatory medications. The study is led by the University of Split School of Medicine in Split, Croatia.
Why it matters
Potential benefit: If successful, participants may experience improved skin hydration and barrier function after irritation when using the Helichrysum extract cream.
How similar studies have gone: Previous research in similar topical plant extracts has shown potential benefits for skin barrier measures, but results vary and this study tests a specific Helichrysum extract formulation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy volunteers who gave written informed consent Exclusion Criteria: * skin disease * skin damage on measurement sites * use of corticosteroids, antihistamines and immunomodulators a month prior the inclusion and during the trial * pregnancy or breastfeeding * immunosuppression * allergic or irritant reactions to the constituents of the cream
Where it's running
-
University of Split School of Medicine
Split, Croatia Recruiting
Study contacts
- Study coordinator: Josipa Bukić
- Email: jbukic@mefst.hr
- Phone: +385917933753
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Peptide cream on forearm skin: does it speed up barrier recovery
A peptide-based cream with Acetyl Hexapeptide-37 is tested on healthy adults to see if it helps the skin recover faster after a mild disruption compared with a placebo.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.