Clinical trial Recruiting at 1 site Interventional Ages 18 to 55

Pentoxifylline to boost liver regrowth after right‑lobe donor hepatectomy

Official title: Effect of Pentoxifylline on Liver Regeneration After Right Lobe Donor Hepatectomy: A Randomized Control Trial

Run by Institute of Liver and Biliary Sciences, India · NCT07085806 · Data updated 2026-11-12

This will try giving pentoxifylline to live liver donors having right‑lobe hepatectomy to see if the remaining liver grows faster and lowers the risk of post‑surgery liver problems.

More Liver Regeneration trials

Quick facts

Study typeInterventional
Ages18 Years to 55 Years
SexAll
Enrollment60 (estimated)
SponsorInstitute of Liver and Biliary Sciences, India
Academic / other
Locations1 site (New Delhi)
StatusRecruiting
StartedJanuary 1, 2025
Main results expectedJuly 15, 2025
Study endsJuly 31, 2025
Registry record updatedJuly 25, 2025
Trial IDNCT07085806 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Healthy live liver donors scheduled for right‑lobe donor hepatectomy who provide informed consent and have no known hypersensitivity to pentoxifylline are the intended participants.

Probably not a fit

People who decline consent or who have hypersensitivity to pentoxifylline (or who are not undergoing right‑lobe donor hepatectomy) would not be eligible and therefore would not receive potential benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, controlled interventional trial at a single tertiary liver center comparing injection pentoxifylline with a control (Plasmalyte) in live donors undergoing right‑lobe hepatectomy. The drug is given perioperatively and donors are followed with clinical exams, blood tests of liver function, and imaging to track liver volume and recovery. The main aim is to determine whether pentoxifylline improves markers of liver regeneration and reduces posthepatectomy liver dysfunction. Eligible participants are consenting live donors without hypersensitivity to pentoxifylline.

Why it matters

Potential benefit: If successful, pentoxifylline could speed liver regrowth and reduce the risk of posthepatectomy liver failure in live donors, improving donor safety.

How similar studies have gone: Prior randomized trials in non‑cirrhotic patients and animal studies have reported beneficial effects of pentoxifylline on small remnant liver regeneration and protection from small‑for‑size syndrome.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* All live donors undergoing Right Donor Hepatectomy after ethical board clearance in the Department of HPB Surgery and Liver Transplantation

Exclusion Criteria:

* Negative consent Hypersensitivity to Pentoxifylline

Where it's running

  • Institute of Liver and Biliary Sciences
    New Delhi, India
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.