Pentoxifylline to boost liver regrowth after right‑lobe donor hepatectomy
Official title: Effect of Pentoxifylline on Liver Regeneration After Right Lobe Donor Hepatectomy: A Randomized Control Trial
Run by Institute of Liver and Biliary Sciences, India · NCT07085806 · Data updated 2026-11-12
This will try giving pentoxifylline to live liver donors having right‑lobe hepatectomy to see if the remaining liver grows faster and lowers the risk of post‑surgery liver problems.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Institute of Liver and Biliary Sciences, India Academic / other |
| Locations | 1 site (New Delhi) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | July 15, 2025 |
| Study ends | July 31, 2025 |
| Registry record updated | July 25, 2025 |
| Trial ID | NCT07085806 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy live liver donors scheduled for right‑lobe donor hepatectomy who provide informed consent and have no known hypersensitivity to pentoxifylline are the intended participants.
✕Probably not a fit
People who decline consent or who have hypersensitivity to pentoxifylline (or who are not undergoing right‑lobe donor hepatectomy) would not be eligible and therefore would not receive potential benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, controlled interventional trial at a single tertiary liver center comparing injection pentoxifylline with a control (Plasmalyte) in live donors undergoing right‑lobe hepatectomy. The drug is given perioperatively and donors are followed with clinical exams, blood tests of liver function, and imaging to track liver volume and recovery. The main aim is to determine whether pentoxifylline improves markers of liver regeneration and reduces posthepatectomy liver dysfunction. Eligible participants are consenting live donors without hypersensitivity to pentoxifylline.
Why it matters
Potential benefit: If successful, pentoxifylline could speed liver regrowth and reduce the risk of posthepatectomy liver failure in live donors, improving donor safety.
How similar studies have gone: Prior randomized trials in non‑cirrhotic patients and animal studies have reported beneficial effects of pentoxifylline on small remnant liver regeneration and protection from small‑for‑size syndrome.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All live donors undergoing Right Donor Hepatectomy after ethical board clearance in the Department of HPB Surgery and Liver Transplantation Exclusion Criteria: * Negative consent Hypersensitivity to Pentoxifylline
Where it's running
-
Institute of Liver and Biliary Sciences
New Delhi, India Recruiting
Study contacts
- Study coordinator: Parneet Dr
- Email: parneet.sunam@gmail.com
- Phone: +917888524169
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How ALPPS surgery affects liver regrowth after major liver cancer operations
This project will follow adults with liver cancer who undergo ALPPS surgery to see if the quickly regrown liver tissue works well and how that relates to cancer coming back.
-
Using breath carbon monoxide to predict liver recovery after partial hepatectomy
This will test whether measuring carbon monoxide in breath can help predict how well adults recover liver function after part of their liver is removed.
-
Using high-dose insulin therapy to enhance liver function before surgery
This study is testing if high-dose insulin therapy can help improve liver function in patients who are about to have major liver surgery.
-
Digital planning for implants in the upper back jaw after a sinus lift
This project will test whether digital planning and the position of implants after a sinus lift affect bone levels, gum health, crown shape, and patient satisfaction in adults with implants in the upper back jaw.
-
Guided bone regeneration using xenograft mixed with donor (allogenic) bone versus xenograft mixed with your own (autogenous) bone to rebuild upper jaw ridges
This will test whether mixing xenograft with donor bone works as well as mixing xenograft with a patient's own bone to rebuild narrow upper jaw ridges before implant placement.
-
Rebuilding bone in the lower back jaw with resorbable or non‑resorbable membranes
This trial tests whether a resorbable pericardium membrane or a non‑resorbable PTFE membrane better helps rebuild horizontal bone in the lower back jaw for people who need bone grafting before dental implants.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.